Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

被引：71

作者：

Mitchell, Daniel E. ^{[1
,2
]}

Cameron, Neil R. ^{[3
,4
]}

Gibson, Matthew I. ^{[1
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Warwick, MOAC Doctoral Training Ctr, Coventry CV4 7AL, W Midlands, England

[3] Monash Univ, Dept Mat Sci & Engn, Clayton, Vic 3800, Australia

[4] Univ Warwick, Sch Engn, Coventry CV4 7AL, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 65期

基金：

英国工程与自然科学研究理事会;

关键词：

ICE CRYSTAL-GROWTH; POLY(VINYL ALCOHOL); GLYCOPROTEINS; INHIBITION; RECRYSTALLIZATION; PEPTIDES; GLYCOPEPTIDES; ANALOGS;

D O I：

10.1039/c5cc04647e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antifreeze (glyco) proteins AF(G) Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

引用

页码：12977 / 12980

页数：4

共 27 条

[1] The aging population poses a global challenge for blood services [J].

Ali, Akif ;

Auvinen, Marja-Kaisa ;

Rautonen, Jukka .

TRANSFUSION, 2010, 50 (03) :584-588

[2] Structurally diverse disaccharide analogs of antifreeze glycoproteins and their ability to inhibit ice recrystallization [J].

Balcerzak, Anna K. ;

Ferreira, Sandra S. ;

Trant, John F. ;

Ben, Robert N. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (04) :1719-1721

[3] Potent inhibition of ice recrystallization by low molecular weight carbohydrate-based surfactants and hydrogelators [J].

Capicciotti, Chantelle J. ;

Leclere, Mathieu ;

Perras, Frederic A. ;

Bryce, David L. ;

Paulin, Hilary ;

Harden, James ;

Liu, Yun ;

Ben, Robert N. .

CHEMICAL SCIENCE, 2012, 3 (05) :1408-1416

[4] ANTIFREEZE PROTEIN MODULATES CELL-SURVIVAL DURING CRYOPRESERVATION - MEDIATION THROUGH INFLUENCE ON ICE CRYSTAL-GROWTH [J].

CARPENTER, JF ;

HANSEN, TN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :8953-8957

[5] Superheating of ice crystals in antifreeze protein solutions [J].

Celik, Yeliz ;

Graham, Laurie A. ;

Mok, Yee-Foong ;

Bar, Maya ;

Davies, Peter L. ;

Braslavsky, Ido .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (12) :5423-5428

[6]

Cheng C.C., 1991, P1

[7] Antifreeze (Glyco)protein Mimetic Behavior of Poly(vinyl alcohol): Detailed Structure Ice Recrystallization Inhibition Activity Study [J].

Congdon, Thomas ;

Notman, Rebecca ;

Gibson, Matthew I. .

BIOMACROMOLECULES, 2013, 14 (05) :1578-1586

[8] Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules [J].

Corcilius, Leo ;

Santhakumar, Gajan ;

Stone, Robin S. ;

Capicciotti, Chantelle J. ;

Joseph, Soumya ;

Matthews, Jacqueline M. ;

Ben, Robert N. ;

Payne, Richard J. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 21 (12) :3569-3581

[9] The importance of hydration for inhibiting ice recrystallization with C-linked antifreeze glycoproteins [J].

Czechura, Pawel ;

Tam, Roger Y. ;

Dimitrijevic, Elena ;

Murphy, Anastasia V. ;

Ben, Robert N. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (10) :2928-2929

[10] Synthetic polymers enable non-vitreous cellular cryopreservation by reducing ice crystal growth during thawing [J].

Deller, Robert C. ;

Vatish, Manu ;

Mitchell, Daniel A. ;

Gibson, Matthew I. .

NATURE COMMUNICATIONS, 2014, 5

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