A novel injectable temperature-sensitive zinc doped chitosan/β-glycerophosphate hydrogel for bone tissue engineering

被引：131

作者：

Niranjan, Ramesh ^{[1
]}

Koushik, Chandru ^{[1
]}

Saravanan, Sekaran ^{[1
]}

Moorthi, Ambigapathi ^{[1
]}

Vairamani, Mariappanadar ^{[1
]}

Selvamurugan, Nagarajan ^{[1
]}

机构：

[1] SRM Univ, Sch Bioengn, Dept Biotechnol, Kattankulathur 603203, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 54卷

关键词：

Hydrogel; Zinc; Chitosan; Antibacterial activity; Osteoblast differentiation; ANTIMICROBIAL ACTIVITY; CELL MINERALIZATION; COMPOSITE SCAFFOLDS; OUTER-MEMBRANE; DIFFERENTIATION; PARTICLES; NETWORKS; CULTURE; COPPER; AGENT;

D O I：

10.1016/j.ijbiomac.2012.11.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/beta-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (beta-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling studies. The hydrogel enhanced antibacterial activity and promoted osteoblast differentiation. Thus, we suggest that the Zn-CS/beta-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：24 / 29

页数：6

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