The antibacterial shield of the human urinary tract

被引：21

作者：

Zasloff, Michael ^{[1
]}

机构：

[1] Georgetown Univ, Sch Med, Georgetown Transplant Inst, Washington, DC USA

来源：

KIDNEY INTERNATIONAL | 2013年 / 83卷 / 04期

关键词：

ANTIMICROBIAL PEPTIDE; RIBONUCLEASE; 7; DEFENSE; CONTRIBUTES;

D O I：

10.1038/ki.2012.467

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Antibacterial peptides and proteins maintain the sterility of the human urinary tract. A broad-spectrum antimicrobial protein, ribonuclease 7 (RNase 7), previously discovered to play a role in controlling the growth of bacteria on human skin, has now been shown to have an important antibacterial function in the human urinary tract. Kidney International (2013) 83, 548-550. doi:10.1038/ki.2012.467

引用

页码：548 / 550

页数：4

共 11 条

[1] Differentiation of Intercalated Cells in the Kidney [J].

Al-Awqati, Qais ;

Gao, Xaio Bo .

PHYSIOLOGY, 2011, 26 (04) :266-272

[2] The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection [J].

Chromek, Milan ;

Slamova, Zuzana ;

Bergman, Peter ;

Kovacs, Laszlo ;

Podracka, L'udmila ;

Ehren, Ingrid ;

Hokfelt, Tomas ;

Gudmundsson, Gudmundur H. ;

Gallo, Richard L. ;

Agerberth, Birgitta ;

Brauner, Annelie .

NATURE MEDICINE, 2006, 12 (06) :636-641

[3] RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin [J].

Harder, J ;

Schröder, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :46779-46784

[4] The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity [J].

Huang, Yu-Chie ;

Lin, Yu-Min ;

Chang, Ting-Wei ;

Wu, Shih-Jung ;

Lee, Yan-Shin ;

Chang, Margaret Dah-Tsyr ;

Chen, Chinpan ;

Wu, Shih-Hsiung ;

Liao, You-Di .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (07) :4626-4633

[5] RNase 7 Contributes to the Cutaneous Defense against Enterococcus faecium [J].

Koeten, Bente ;

Simanski, Maren ;

Glaeser, Regine ;

Podschun, Rainer ;

Schroeder, Jens-Michael ;

Harder, Juergen .

PLOS ONE, 2009, 4 (07)

[6]

Schmaldienst Sabine, 2002, Curr Opin Urol, V12, P125, DOI 10.1097/00042307-200203000-00007

[7] Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract [J].

Spencer, John D. ;

Schwaderer, Andrew L. ;

DiRosario, Julianne D. ;

McHugh, Kirk M. ;

McGillivary, Glen ;

Justice, Sheryl S. ;

Carpenter, Ashley R. ;

Baker, Peter B. ;

Harder, Juergen ;

Hains, David S. .

KIDNEY INTERNATIONAL, 2011, 80 (02) :175-181

[8] Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract [J].

Spencer, John David ;

Schwaderer, Andrew L. ;

Wang, Huanyu ;

Bartz, Julianne ;

Kline, Jennifer ;

Eichler, Tad ;

DeSouza, Kristin R. ;

Sims-Lucas, Sunder ;

Baker, Peter ;

Hains, David S. .

KIDNEY INTERNATIONAL, 2013, 83 (04) :615-625

[9] Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract [J].

Spencer, John David ;

Hains, David S. ;

Porter, Edith ;

Bevins, Charles L. ;

DiRosario, Julianne ;

Becknell, Brian ;

Wang, Huanyu ;

Schwaderer, Andrew L. .

PLOS ONE, 2012, 7 (02)

[10] Antimicrobial peptides of multicellular organisms [J].

Zasloff, M .

NATURE, 2002, 415 (6870) :389-395

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