The antibacterial shield of the human urinary tract

被引:20
作者
Zasloff, Michael [1 ]
机构
[1] Georgetown Univ, Sch Med, Georgetown Transplant Inst, Washington, DC USA
关键词
ANTIMICROBIAL PEPTIDE; RIBONUCLEASE; 7; DEFENSE; CONTRIBUTES;
D O I
10.1038/ki.2012.467
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Antibacterial peptides and proteins maintain the sterility of the human urinary tract. A broad-spectrum antimicrobial protein, ribonuclease 7 (RNase 7), previously discovered to play a role in controlling the growth of bacteria on human skin, has now been shown to have an important antibacterial function in the human urinary tract. Kidney International (2013) 83, 548-550. doi:10.1038/ki.2012.467
引用
收藏
页码:548 / 550
页数:4
相关论文
共 11 条
[1]   Differentiation of Intercalated Cells in the Kidney [J].
Al-Awqati, Qais ;
Gao, Xaio Bo .
PHYSIOLOGY, 2011, 26 (04) :266-272
[2]   The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection [J].
Chromek, Milan ;
Slamova, Zuzana ;
Bergman, Peter ;
Kovacs, Laszlo ;
Podracka, L'udmila ;
Ehren, Ingrid ;
Hokfelt, Tomas ;
Gudmundsson, Gudmundur H. ;
Gallo, Richard L. ;
Agerberth, Birgitta ;
Brauner, Annelie .
NATURE MEDICINE, 2006, 12 (06) :636-641
[3]   RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin [J].
Harder, J ;
Schröder, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (48) :46779-46784
[4]   The flexible and clustered lysine residues of human ribonuclease 7 are critical for membrane permeability and antimicrobial activity [J].
Huang, Yu-Chie ;
Lin, Yu-Min ;
Chang, Ting-Wei ;
Wu, Shih-Jung ;
Lee, Yan-Shin ;
Chang, Margaret Dah-Tsyr ;
Chen, Chinpan ;
Wu, Shih-Hsiung ;
Liao, You-Di .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (07) :4626-4633
[5]   RNase 7 Contributes to the Cutaneous Defense against Enterococcus faecium [J].
Koeten, Bente ;
Simanski, Maren ;
Glaeser, Regine ;
Podschun, Rainer ;
Schroeder, Jens-Michael ;
Harder, Juergen .
PLOS ONE, 2009, 4 (07)
[6]  
Schmaldienst Sabine, 2002, Curr Opin Urol, V12, P125, DOI 10.1097/00042307-200203000-00007
[7]   Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract [J].
Spencer, John D. ;
Schwaderer, Andrew L. ;
DiRosario, Julianne D. ;
McHugh, Kirk M. ;
McGillivary, Glen ;
Justice, Sheryl S. ;
Carpenter, Ashley R. ;
Baker, Peter B. ;
Harder, Juergen ;
Hains, David S. .
KIDNEY INTERNATIONAL, 2011, 80 (02) :175-181
[8]   Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract [J].
Spencer, John David ;
Schwaderer, Andrew L. ;
Wang, Huanyu ;
Bartz, Julianne ;
Kline, Jennifer ;
Eichler, Tad ;
DeSouza, Kristin R. ;
Sims-Lucas, Sunder ;
Baker, Peter ;
Hains, David S. .
KIDNEY INTERNATIONAL, 2013, 83 (04) :615-625
[9]   Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract [J].
Spencer, John David ;
Hains, David S. ;
Porter, Edith ;
Bevins, Charles L. ;
DiRosario, Julianne ;
Becknell, Brian ;
Wang, Huanyu ;
Schwaderer, Andrew L. .
PLOS ONE, 2012, 7 (02)
[10]   Antimicrobial peptides of multicellular organisms [J].
Zasloff, M .
NATURE, 2002, 415 (6870) :389-395