Cushing Syndrome in Pediatrics

被引：98

作者：

Stratakis, Constantine A. ^{[1
,2
]}

机构：

[1] NICHHD, Pediat Endocrinol Training Program, NIH, CRC, Bethesda, MD 20892 USA

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Endocrinol & Genet, Program Dev Endocrinol & Genet, NIH, Bethesda, MD 20892 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Cushing syndrome; Pituitary tumors; Cortisol; Adrenal cortex; Carney complex; Adrenocortical hyperplasia; Adrenal cancer; CORTICOTROPIN-RELEASING HORMONE; NODULAR ADRENOCORTICAL DISEASE; DIFFERENTIAL-DIAGNOSIS; ADRENAL-HYPERPLASIA; PITUITARY-ADENOMAS; SYNDROME SECONDARY; CHILDREN; ADOLESCENTS; MUTATIONS; DEXAMETHASONE;

D O I：

10.1016/j.ecl.2012.08.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cushing syndrome is characterized by truncal obesity, growth deceleration, skin changes, muscle weakness, and hypertension. Cushing syndrome in childhood usually results from the exogenous administration of glucocorticoids. This article presents the causes and discusses the treatment of endogenous Cushing syndrome. It also discusses the clinical and molecular genetics of inherited forms of this syndrome. Cushing syndrome needs to be diagnosed and treated properly when first recognized; improper treatment can turn this otherwise completely curable disorder into a chronic ailment. Barriers to optimal care of a pediatric patient with Cushing syndrome are discussed.

引用

收藏

页码：793 / +

页数：13

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