Expression of SKP2 protein in lung carcinoma

Objective: To study the expressive characteristics of SKP2 protein in lung carcinoma and its implication for prognosis. Methods: The expression of SKP2 protein was detected in 89 non small cell lung carcinoma, 13 small cell lung carcinoma, 10 lung benign lesion tissues by Tissue Chip and Immunohistochemistry technology. Results: The positive rate of SKP2 protein staining was (23.52 +/- 13.57)% in non small cell lung carcinoma and (53.85 +/- 12.26)% in small cell lung carcinoma, which were significantly higher than (2.91 +/- 1.27)% in lung benign lesion tissues. It was highest in small cell lung carcinoma and lowest in lung benign lesion tissues, with a significant difference between them (P=0.000). The expressive level of SKP2 protein in lung carcinoma tissues was closely related to cell differentiation, lymph node metastasis and pathological types, but not to age, sex, smoking history, tumor site and size, and TNM staging. The survival analysis revealed that the 5-year survival rate of lung carcinoma patients was lower in SKP2 protein positive expression group than that in negative expression group (P-1=0.003/0.002; r=-0.275, P-2=0.005). Conclusion: The positive expression of SKP2 protein is higher in lung carcinoma than in lung benign lesion tissues, in particular, much higher in small cell lung carcinoma. In lung carcinoma, its expressive level was closely related to cell differentiation, lymph node metastasis and pathological types. Moreover, it may be an independent factor to prognosis of patients with lung carcinoma.