Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues

被引：19
作者：
Okada, A
Saez, S
Misumi, Y
Basset, P
机构：
[1] UNIV STRASBOURG 1,CNRS,INSERM,F-67404 ILLKIRCH GRAFFENS,FRANCE
[2] FUKUOKA UNIV,SCH MED,DEPT BIOCHEM,JAONAN KU,FUKUOKA 81480,JAPAN
[3] INST PASTEUR,LAB BIOL TISSUS TUMORAUX,UNITE RADIOANAL,F-69365 LYON 07,FRANCE
来源：
GENE | 1997年 / 185卷 / 02期
关键词：
matrix metalloproteinase; rat tissues; rat mammary tumor;
D O I：
10.1016/S0378-1119(96)00615-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
From a rat skin wound healing cDNA library, a clone encoding stromelysin 3 (ST3) was isolated. The predicted rat ST3 has 491 amino acids, and shows 83, 95 and 58% homology with human, mouse and Xenopus ST3, respectively. COS-I cells transfected with this rat ST3 cDNA produced the ST3 preform, which could be converted to the mature ST3 form by co-transfection with rat furin cDNA. In addition to healing skin, the rat ST3 gene was found to be strongly expressed in normal adult uterus and ovary, and at lower levels in chemically-induced mammary tumors.
引用
收藏
页码：187 / 193
页数：7
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