18F autoradiography using pixelated CMOS technology

被引：0
|
作者：
Truong Nguyen Pham [1 ]
Finck, Christian [1 ]
Marchand, Patrice [1 ]
Brasse, David [1 ]
Boisson, Frederic [1 ]
Laquerriere, Patrice [1 ]
机构：
[1] Univ Strasbourg, CNRS, IPHC, UMR 7178, F-67000 Strasbourg, France
来源：
2017 IEEE 15TH INTERNATIONAL NEW CIRCUITS AND SYSTEMS CONFERENCE (NEWCAS) | 2017年
关键词：
Autoradiography; CMOS sensor; Fluorine; 18; QUANTITATIVE AUTORADIOGRAPHY; DETECTOR; RESOLUTION; BRAIN; PET; LOCALIZATION; SECTIONS; SENSORS; TISSUES;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Autoradiography is a method that allows to take ex-vivo images of thin sections of tissue labelled with a radioactive tracer. In the present work, we aim to study the feasibility of autoradiography with CMOS (Complementary Metal Oxide Semiconductor) Mimosa-28 by using 2-Deoxy-2-F-18-fluoro-D-glucose (F-18-FDG). Autoradiography allows a functional imaging pixelated with a resolution equivalent to optical microscopy. In this paper, we report the characterisation of the Mimosa28 sensor. The sensor presents a linearity detection of positrons emitted from F-18 with an activity from 450Bq to 3kBq. The detection efficiency was 77.660% +/- 0.024% for a source in contact with the sensor. The spatial resolution was 153 mu m +/- 7 mu m. Mimosa-28 CMOS sensor demonstrates the capability to do autoradiography of a tissue section labelled with F-18-FDG.
引用
收藏
页码：41 / 44
页数：4
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