Photoredox-Induced Three-Component Oxy-, Amino-, and Carbotrifluoromethylation of Enecarbamates

被引：189

作者：

Carboni, Aude ^{[1
]}

Dagousset, Guillaume ^{[1
]}

Magnier, Emmanuel ^{[2
]}

Masson, Geraldine ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

[2] Univ Versailles St Quentin, Inst Lavoisier Versailles, UMR 8180, F-78035 Versailles, France

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 04期

关键词：

VISIBLE-LIGHT PHOTOCATALYSIS; COPPER-CATALYZED TRIFLUOROMETHYLATION; CHIRAL PHOSPHORIC-ACID; AZA-MICHAEL ADDITION; ONE-POT SYNTHESIS; ALPHA-TRIFLUOROMETHYL; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; ALKENES; EFFICIENT;

D O I：

10.1021/ol500374e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A photoredox-catalzyed trifluoromethylation of enecarbamates process is reported. This pathway uses Togni's reagent as the CF3 source and follows a radical/cationic pathway. Under the optimized conditions using [Ru(bpy)(3)(PF6)(2)] as the photocatalyst, a wide range of substituted enecarbamates can readily be difunctionalized by means of various O, N, and C nudeophiles.

引用

页码：1240 / 1243

页数：4

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