Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells

被引：16
作者：
Khan, Shaukat Ali [1 ]
Nowatzky, Johannes [1 ,2 ]
Jimenez-Branda, Sonia [1 ]
Greenberg, Jeffrey David [2 ]
Clancy, Robert [2 ]
Buyon, Jill [2 ]
Bhardwaj, Nina [1 ]
机构：
[1] NYU, Sch Med, Inst Canc, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Med, Div Rheumatol,NYU Hosp Joint Dis, New York, NY 10003 USA
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2013年 / 95卷 / 02期
关键词：
Systemic lupus erythematosus; Dendritic cells; Disease activity; Autoimmunity; PATHOGENESIS; INDUCTION;
D O I：
10.1016/j.yexmp.2013.06.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objective: The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. Methods: Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI >= 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation. Results: The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality. Conclusion: cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：121 / 123
页数：3
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