Active systemic lupus erythematosus is associated with decreased blood conventional dendritic cells

被引：16
作者：
Khan, Shaukat Ali [1 ]
Nowatzky, Johannes [1 ,2 ]
Jimenez-Branda, Sonia [1 ]
Greenberg, Jeffrey David [2 ]
Clancy, Robert [2 ]
Buyon, Jill [2 ]
Bhardwaj, Nina [1 ]
机构：
[1] NYU, Sch Med, Inst Canc, New York, NY 10016 USA
[2] NYU, Sch Med, Dept Med, Div Rheumatol,NYU Hosp Joint Dis, New York, NY 10003 USA
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2013年 / 95卷 / 02期
关键词：
Systemic lupus erythematosus; Dendritic cells; Disease activity; Autoimmunity; PATHOGENESIS; INDUCTION;
D O I：
10.1016/j.yexmp.2013.06.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Objective: The aim of the study is to determine the frequency and functionality of blood conventional dendritic cells (cDCs) in relation to disease activity in systemic lupus erythematosus. Methods: Blood cDCs were enumerated for 34 SLE patients, defined as "active" (SLEDAI >= 4) or "inactive" (SLEDAI < 4), 26 RA subjects and 8 healthy subjects by FACS. cDC activation was measured by IL-12p40/70 staining following resiquimod stimulation. Results: The frequency of blood cDCs was significantly lower in active compared to inactive patients, however, with comparable cDC functionality. Conclusion: cDC frequency in active SLE is decreased with no perturbation in cDC function, possibly due to enhanced turnover and/or tissue-specific migration. (c) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：121 / 123
页数：3
相关论文
共 13 条
[1]   Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].
Blanco, P ;
Palucka, AK ;
Gill, M ;
Pascual, V ;
Banchereau, J .
SCIENCE, 2001, 294 (5546) :1540-1543
[2]   The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus [J].
Crispin, Jose C. ;
Alcocer-Varela, Jorge .
AUTOIMMUNITY REVIEWS, 2007, 6 (07) :450-456
[3]   Phenotype and function of dendritic cells of patients with systemic lupus erythematosus [J].
Crispin, Jose C. ;
Ines Vargas-Rojas, Maria ;
Monsivais-Urenda, Adriana ;
Alcocer-Varela, Jorge .
CLINICAL IMMUNOLOGY, 2012, 143 (01) :45-50
[4]  
Gerl V., 2012, ANN RHEUM DIS, V69, P1370
[5]   Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus [J].
Henriques, Ana ;
Ines, Luis ;
Carvalheiro, Tiago ;
Couto, Maura ;
Andrade, Angela ;
Pedreiro, Susana ;
Laranjeira, Paula ;
Morgado, Jose Mario ;
Pais, Maria Luisa ;
Pereira da Silva, Jose Antonio ;
Paiva, Artur .
RHEUMATOLOGY INTERNATIONAL, 2012, 32 (04) :863-869
[6]   Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression [J].
Jin, On ;
Kavikondala, Susluna ;
Fu, Lingyun Sun Rong ;
Mok, Mo-Yin ;
Chan, Albert ;
Yeung, Joseph ;
Lau, Chak-Sing .
LUPUS, 2008, 17 (07) :654-662
[7]   Dendritic cell function in lupus: Independent contributors or victims of aberrant immune regulation [J].
Kis-Toth, Katalin ;
Tsokos, George C. .
AUTOIMMUNITY, 2010, 43 (02) :121-130
[8]   Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus [J].
Nie, Ying J. ;
Mok, Mo Y. ;
Chan, Godfrey C. F. ;
Chan, Albert W. ;
Jin, Ou ;
Kavikondala, Sushma ;
Lie, Albert K. W. ;
Lau, Chak S. .
ARTHRITIS RESEARCH & THERAPY, 2010, 12 (03)
[9]   Combined oral contraceptives in women with systemic lupus erythematosus [J].
Petri, M ;
Kim, MY ;
Kalunian, KC ;
Grossman, J ;
Hahn, BH ;
Sammaritano, LR ;
Lockshin, M ;
Merrill, JT ;
Belmont, HM ;
Askanase, AD ;
McCune, WJ ;
Hearth-Holmes, M ;
Dooley, MA ;
Von Feldt, J ;
Friedman, A ;
Tan, M ;
Davis, J ;
Cronin, M ;
Diamond, B ;
Mackay, M ;
Sigler, L ;
Fillius, M ;
Rupel, A ;
Licciardi, F ;
Buyon, JP .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (24) :2550-2558
[10]  
Scheinecker C, 2001, ARTHRITIS RHEUM, V44, P856, DOI 10.1002/1529-0131(200104)44:4<856::AID-ANR142>3.0.CO
12