Personalizing immunotherapy Balancing predictability and precision

被引：12

作者：

Agur, Zvia ^{[1
]}

Vuk-Pavlovic, Stanimir ^{[2
]}

机构：

[1] Inst Med BioMath, Bene Ataroth, Israel

[2] Mayo Clin, Coll Med, Rochester, MN USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 07期

关键词：

mathematical model; in-treatment; personalization; prostate cancer; clinical trial; CANCER;

D O I：

10.4161/onci.20955

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite great expectations and research efforts, anticancer immunotherapy has not yet become a definitive cure. Perhaps, this is because past reductionist approaches were too simplistic for the patient-specific complex system of co-evolving tumor cells and host immunity. Recent efforts based on a systems-based approach promise improved clinical outcomes engendered by a dynamic modification of personalized therapeutic regimens.

引用

收藏

页码：1169 / 1171

页数：3

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