Sesquiterpenes and neolignans from the roots of Illicium dunnianum

被引：18

作者：

Bai, Jian ^{[1
,2
]}

Chen, Hui ^{[1
,2
]}

Fang, Zhen-Feng ^{[1
,2
]}

Yu, Shi-Shan ^{[1
,2
]}

Ma, Shuang-Gang ^{[1
,2
]}

Li, Yong ^{[1
,2
]}

Qu, Jing ^{[1
,2
]}

Xu, Song ^{[1
,2
]}

Ren, Jing-Hong ^{[1
,2
]}

Lu, Hai-Ning ^{[1
,2
]}

Chen, Xia ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 10期

关键词：

Illicium dunnianum; Illiciaceae; sesquiterpene; neolignan; glycoside; antioxidant activities; LIGNANS; GLYCOSIDES; BARK;

D O I：

10.1080/10286020.2012.729507

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpenes, dunnianoside I (1) and 8'-oxo-6-hydroxy-dihydrophaseic acid methyl ester (2), a new glycoside, dunnianoside J (3), two new neolignans, dunnianeolignans A-B (4, 5), together with 10 known compounds (6-15), were isolated from the roots of Illicium dunnianum. The structures of these new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-ESI-MS, and chemical methods. Compounds 7, 8, and 13-15 exhibited potent antioxidant activities against Fe2+-cystine-induced rat liver microsomal lipid peroxidation, with IC50 values ranging from 4.2 +/- 0.4 to 38.4 +/- 2.6 mu M.

引用

页码：940 / 949

页数：10

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