Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C

被引：47
作者：
Bates, Robert H. [1 ]
Shotwell, J. Brad [2 ]
Roush, William R. [1 ,2 ]
机构：
[1] Scripps Florida, Dept Chem, Jupiter, FL 33458 USA
[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 19期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1021/ol801852j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Stereoselective syntheses of the C(1)-C(9) fragments 18 and 28 of amphidinolide C have been developed. The first-generation sequence involves a diastereoselective chelate-controlled [3 + 2]-annulation reaction of 6 and 7, while the second-generation synthesis involves an intramolecular hetero-Michael cyclization of 8.
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页码：4343 / 4346
页数：4
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