Possible neuroprotective mechanism of human neuroglobin

被引：43

作者：

Wakasugi, K

Kitatsuji, C

Morishima, I

机构：

[1] Kyoto Univ, Dept Mol Engn, Grad Sch Engn, Kyoto 6158510, Japan

[2] Japan Sci & Technol Agcy, PRESTO, Saitama 3320012, Japan

来源：

NEUROPROTECTIVE AGENTS | 2005年 / 1053卷

关键词：

neuroglobin (Ngb); protein-protein interaction; oxidative stress; neuroprotection; HETEROTRIMERIC G-PROTEINS; CYSTATIN-C; INDUCED APOPTOSIS; GOLOCO MOTIF; NITRIC-OXIDE; HEMOGLOBIN; GLOBIN; EXPRESSION; MYOGLOBIN; PROTECTS;

D O I：

10.1196/annals.1344.020

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuroglobin (Ngb) is a newly discovered hexacoordinate globin that is expressed in vertebrate brain and can reversibly bind oxygen. Expression of Ngb increases in response to oxygen deprivation and protects neurons from hypoxia in vitro and in vivo. Recent work on human Ngb has shed light on the mechanism of this neuroprotection by human Ngb, as discussed in this review. Human ferric Ngb has been found to act as a guanine nucleotide dissociation inhibitor for the a subunit of heterotrimeric G proteins. Moreover, other Ngb-binding proteins also have been identified. These findings suggest that human Ngb may function as a regulator of signal transduction in the brain.

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页码：220 / 230

页数：11

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