Effects of Selenium and Exendin-4 on Glucagon-Like Peptide-1 Receptor, IRS-1, and Raf-1 in the Liver of Diabetic Rats

被引：10

作者：

Barakat, Ghinwa M. ^{[2
]}

Moustafa, Mohamed E. ^{[1
,2
]}

Bikhazi, Anwar B. ^{[3
]}

机构：

[1] Univ Alexandria, Dept Biochem, Fac Sci, Alexandria 21511, Egypt

[2] Beirut Arab Univ, Dept Biol & Environm Sci, Fac Sci, Beirut, Lebanon

[3] Amer Univ Beirut, Dept Physiol, Fac Med, Beirut, Lebanon

来源：

BIOCHEMICAL GENETICS | 2012年 / 50卷 / 11-12期

关键词：

Antidiabetic; Diabetes mellitus; Exendin-4; GLP-1; receptor; Glutathione peroxidase-1; DEPENDENT INSULINOTROPIC POLYPEPTIDE; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; BETA-CELL; GLUCOSE; OVEREXPRESSION; STIMULATION; SUBSTRATE-1; MECHANISMS;

D O I：

10.1007/s10528-012-9532-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selenium and exendin-4 exert antidiabetic effects by unknown mechanisms. Herein, we investigated their effects on the expression of glucagon-like peptide-1 receptor (GLP-1R), insulin receptor substrate-1 (IRS-1), and Raf-1 in the livers of rats with streptozotocin-induced diabetes. Diabetic rats were injected intraperitoneally with exendin-4 (0.03 mu g/kg body weight) twice daily or treated with 5 ppm selenium as sodium selenite in drinking water for 4 weeks. Both selenium and exendin-4 reduced the hyperglycemia in diabetic rats. Induction of diabetes mellitus resulted in decreased level of GLP-1R and increased levels of IRS-1 and Raf-1 in the liver. Treatment of diabetic rats with selenium or exendin-4 resulted in increased level of GLP-1R and decreased levels of IRS-1 and Raf-1 in the liver, compared with the levels in diabetic rats. Therefore, the antidiabetic actions of selenium and exendin-4 involve their effects on GLP-1R, IRS-1, and Raf-1 levels in the liver.

引用

页码：922 / 935

页数：14

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