A new diastereoselective multicomponent, one-pot strategy for the synthesis of 3-substituted isoindolinones via efficient C-C bond formation

被引：18
作者：
Wan, Jie-Ping [1 ]
Zhou, Jing [1 ]
Mao, Hui [1 ]
Pan, Yuan-Jiang [1 ]
Wu, An-Xin [2 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
[2] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China
来源：
TETRAHEDRON | 2008年 / 64卷 / 49期
基金：
中国国家自然科学基金;
关键词：
Multicomponent; One-pot; 3-Substituted isoindolinones; C-C bond formation;
D O I：
10.1016/j.tet.2008.09.092
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new three-component reaction among o-phthalaldehyde, N-alkyl/aryl Substituted urea, and an aromatic aldehyde has been developed at ambient condition, and a class of isoindolinones with novel C-3 Substitution were conveniently synthesized. The general diastereomeric excess is high as over 99% of the products indicated the excellent stereoselectivity posed in this multicomponent reaction. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：11115 / 11123
页数：9
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