News and controversies regarding essential tremor

被引:9
作者
Boutin, E. [1 ,2 ]
Vaugoyeau, M. [1 ,2 ]
Eusebio, A. [1 ,2 ]
Azulay, J. -P. [1 ,2 ]
Witjas, T. [1 ,2 ]
机构
[1] CHU Timone, Serv Neurol & Pathol Mouvement, Pole Neurosci Clin, F-13385 Marseille 05, France
[2] CNRS, AMU, LNC, UMR 7291, F-13331 Marseille, France
关键词
Essential tremor; Pathophysiology; Cerebellum; DEEP BRAIN-STIMULATION; VOXEL-BASED MORPHOMETRY; QUALITY STANDARDS SUBCOMMITTEE; FOCUSED ULTRASOUND THALAMOTOMY; BOTULINUM TOXIN TREATMENT; FAMILIAL ESSENTIAL TREMOR; PLACEBO-CONTROLLED TRIAL; GAMMA-KNIFE THALAMOTOMY; CEREBELLAR GRAY-MATTER; ESSENTIAL HEAD TREMOR;
D O I
10.1016/j.neurol.2015.02.007
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Essential tremor is the most common movement disorder in adults. It is characterized by a postural and kinetic tremor affecting the arms, but it can also affect other body parts. It evolves gradually and can be responsible for a functional impairment in activities of daily living. Its pathophysiology remains poorly understood and effective therapeutic options are limited. There are significant semiological variations between patients, and the term "essential tremor" seems to encompass a wide range of heterogeneous clinical phenotypes. The diagnostic criteria presented in 1998 are now challenged. Furthermore, there is a current debate concerning the etiology of this affection, as to whether essential tremor is a complex degenerative disorder or a functional reversible disorder of neuronal oscillation. In this review, we summarize some aspects of clinical, etiologic and therapeutic news, to better address the questioning on unravelling the clinical presentation and examine the current pathophysiological controversy in this disorder. (C) 2015 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:415 / 425
页数:11
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