Alcohol withdrawal syndrome: mechanisms, manifestations, and management

被引:137
作者
Jesse, S. [1 ]
Brathen, G. [2 ,3 ]
Ferrara, M. [4 ]
Keindl, M. [5 ]
Ben-Menachem, E. [6 ]
Tanasescu, R. [7 ,8 ]
Brodtkorb, E. [2 ,3 ]
Hillbom, M. [9 ]
Leone, M. A. [4 ]
Ludolph, A. C. [1 ]
机构
[1] Univ Ulm, Dept Neurol, Ulm, Germany
[2] Univ Trondheim Hosp, Dept Neurol & Clin Neurophysiol, Trondheim, Norway
[3] Norwegian Univ Sci & Technol, Dept Neurosci, Trondheim, Norway
[4] IRCCS Casa Sollievo Sofferenza, Neurol Unit, San Giovanni Rotondo, Italy
[5] Danube Univ Krems, Krems, Austria
[6] SU Sahlgrenska Hosp, Inst Clin Neurosci & Neurophysiol, Gothenburg, Sweden
[7] Univ Med & Pharm Carol Davila, Colentina Hosp, Dept Neurol Neurosurg & Psychiat, Bucharest, Romania
[8] Univ Nottingham, Acad Clin Neurol, Div Clin Neurosci, Nottingham, England
[9] Oulu Univ Hosp, Dept Neurol, Oulu, Finland
来源
ACTA NEUROLOGICA SCANDINAVICA | 2017年 / 135卷 / 01期
关键词
alcohol withdrawal; clinical management; delirium tremens; epileptic seizures; therapy; CARBOHYDRATE-DEFICIENT TRANSFERRIN; SEVERITY SCALE PAWSS; ACID ETHYL-ESTERS; DELIRIUM-TREMENS; SODIUM OXYBATE; DOUBLE-BLIND; EMERGENCY-DEPARTMENT; DEPENDENT INPATIENTS; ETHANOL-CONSUMPTION; STATUS EPILEPTICUS;
D O I
10.1111/ane.12671
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The alcohol withdrawal syndrome is a well-known condition occurring after intentional or unintentional abrupt cessation of heavy/constant drinking in patients suffering from alcohol use disorders (AUDs). AUDs are common in neurological departments with patients admitted for coma, epileptic seizures, dementia, polyneuropathy, and gait disturbances. Nonetheless, diagnosis and treatment are often delayed until dramatic symptoms occur. The purpose of this review is to increase the awareness of the early clinical manifestations of AWS and the appropriate identification and management of this important condition in a neurological setting.
引用
收藏
页码:4 / 16
页数:13
相关论文
共 104 条
[1]   Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome [J].
Amato, Laura ;
Minozzi, Silvia ;
Davoli, Marina .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2011, (06)
[2]   Benzodiazepines for alcohol withdrawal [J].
Amato, Laura ;
Minozzi, Silvia ;
Vecchi, Simona ;
Davoli, Marina .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2010, (03)
[3]  
[Anonymous], COCHRANE DATABASE SY
[4]  
[Anonymous], MAN SUBST AB ALC
[5]  
[Anonymous], 2013, Diagnostic and statistical manual of mental disorders
[6]   The role of carbamazepine and oxcarbazepine in alcohol withdrawal syndrome [J].
Barrons, R. ;
Roberts, N. .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2010, 35 (02) :153-167
[7]   Biomarkers to disclose recent intake of alcohol:: Potential of 5-hydroxytryptophol glucuronide testing using new direct UPLC-tandem MS and ELISA methods [J].
Beck, Olof ;
Stephanson, Nikolai ;
Boettcher, Michael ;
Dahmen, Norbert ;
Fehr, Christoph ;
Helander, Anders .
ALCOHOL AND ALCOHOLISM, 2007, 42 (04) :321-325
[8]   Recommendation for a definition of acute symptomatic seizure [J].
Beghi, Ettore ;
Carpio, Arturo ;
Forsgren, Lars ;
Hesdorffer, Dale C. ;
Malmgren, Kristina ;
Sander, Josemir W. ;
Tomson, Torbjorn ;
Hauser, W. Allen .
EPILEPSIA, 2010, 51 (04) :671-675
[9]   The validity of the laboratory marker combinations DOVER and QUVER to detect physician's diagnosis of at-risk drinking [J].
Bentele, Michael ;
Kriston, Levente ;
Clement, Hans-Willi ;
Haerter, Martin ;
Mundle, Goetz ;
Berner, Michael M. .
ADDICTION BIOLOGY, 2007, 12 (01) :85-92
[10]   Thrombocytopenia in Early Alcohol Withdrawal is Associated with Development of Delirium Tremens or Seizures [J].
Berggren, Ulf ;
Fahlke, Claudia ;
Berglund, Kristina J. ;
Blennow, Kaj ;
Zetterberg, Henrik ;
Balldin, Jan .
ALCOHOL AND ALCOHOLISM, 2009, 44 (04) :382-386