Design, semisynthesis and cytotoxic activity of novel ester derivatives of betulinic acid-1,2,4 oxadiazoles

被引：6

作者：

Challa, Krishna ^{[1
]}

Bhargavi, M. Vijaya ^{[2
]}

Krupadanam, G. L. David ^{[1
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500068, Andhra Pradesh, India

[2] Osmania Univ, Fac Technol, Dept Pharm, Hyderabad 500068, Andhra Pradesh, India

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2016年 / 18卷 / 12期

关键词：

Betulinic acid; 1,2,4-oxadiazole; coupling; ester; pro drug; cytotoxic activity; ACID-DERIVATIVES; BIOLOGICAL EVALUATION; HUMAN-MELANOMA; POTENT; DISCOVERY; APOPTOSIS; GROWTH; AGENTS;

D O I：

10.1080/10286020.2016.1196193

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Taking into consideration of the biological activity of betulinic acid derivatives containing a oxadiazole ring, the semisynthetic betulinic acid-1,2,4-oxadiazole esters (14-25) were synthesized starting from betulinic acid (1) and 5-(bromomethyl)-3-aryl-1,2,4-oxadiazoles (2-13) and final compounds were tested for cytotoxic activity on three human cancer cell lines in vitro. All tested compounds showed good cytotoxic activity. The structures of synthesized compounds are established based on infrared (IR), nuclear magnetic resonance (NMR), and mass spectrometry.

引用

页码：1158 / 1168

页数：11

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