Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis

被引：78

作者：

Mann, Christopher D. ^{[1
]}

Neal, Christopher P. ^{[1
]}

Garcea, Giuseppe ^{[2
]}

Manson, Margaret M. ^{[1
]}

Dennison, Ashley R. ^{[2
]}

Berry, David P. ^{[2
]}

机构：

[1] Univ Leicester, Canc Biomarkers & Prevent Grp, Dept Canc Studies & Mol Med, Bioctr, Leicester LE1 7RH, Leics, England

[2] Univ Hosp Leicester, Leicester Gen Hosp, Dept Hopatobiliary & Pancreat Surg, Leicester, Leics, England

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2009年 / 18卷 / 01期

基金：

英国医学研究理事会;

关键词：

carcinoma; chemoprevention; chemotherapeutics; hepatocellular hepatocarcinogenesis; phytochemicals; N-ACETYLCYSTEINE CONJUGATE; DIETHYLNITROSAMINE-INDUCED HEPATOCARCINOGENESIS; AFLATOXIN B-1-INDUCED CARCINOGENESIS; ISOTHIOCYANATE-MEDIATED APOPTOSIS; HUMAN HEPATOCELLULAR-CARCINOMA; CAPSAICIN-INDUCED APOPTOSIS; LIVER PRENEOPLASTIC FOCI; HEPATOCYTE GROWTH-FACTOR; NATURAL-PRODUCT PRESENT; DECREASES TUMOR-GROWTH;

D O I：

10.1097/CEJ.0b013e3282f0c090

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular carcinoma (HCC) is the fifth commonest malignancy worldwide and the incidence is rising. Surgery, including transplantation resection, is currently the most effective treatment for HCC; however, recurrence rates are high and long-term survival is poor. Identifying novel chemopreventive and chemotherapeutic agents and targeting them to patients at high risk of developing HCC or following curative treatment may go some way towards improving prognosis. This review examines current knowledge regarding the chemopreventive and chemotherapeutic potential of phytochemicals in heptocarcinogenesis. Both in-vitro and animal studies demonstrate that several phytochemicals, including curcumin, resveratrol, green tea catechins, oltipraz and silibinin, possess promising chemopreventive and chemotherapeutic properties. Despite this, very few clinical trials have been performed. Problems regarding validation of biomarkers, agent delivery, side effects and patient selection are barriers that need to be overcome to determine the potential of such agents in clinical practice. European Journal of Cancer Prevention 18:13-25 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：13 / 25

页数：13

共 203 条

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