Phytochemicals as potential chemopreventive and chemotherapeutic agents in hepatocarcinogenesis

被引：78
作者：
Mann, Christopher D. [1 ]
Neal, Christopher P. [1 ]
Garcea, Giuseppe [2 ]
Manson, Margaret M. [1 ]
Dennison, Ashley R. [2 ]
Berry, David P. [2 ]
机构：
[1] Univ Leicester, Canc Biomarkers & Prevent Grp, Dept Canc Studies & Mol Med, Bioctr, Leicester LE1 7RH, Leics, England
[2] Univ Hosp Leicester, Leicester Gen Hosp, Dept Hopatobiliary & Pancreat Surg, Leicester, Leics, England
来源：
EUROPEAN JOURNAL OF CANCER PREVENTION | 2009年 / 18卷 / 01期
基金：
英国医学研究理事会;
关键词：
carcinoma; chemoprevention; chemotherapeutics; hepatocellular hepatocarcinogenesis; phytochemicals; N-ACETYLCYSTEINE CONJUGATE; DIETHYLNITROSAMINE-INDUCED HEPATOCARCINOGENESIS; AFLATOXIN B-1-INDUCED CARCINOGENESIS; ISOTHIOCYANATE-MEDIATED APOPTOSIS; HUMAN HEPATOCELLULAR-CARCINOMA; CAPSAICIN-INDUCED APOPTOSIS; LIVER PRENEOPLASTIC FOCI; HEPATOCYTE GROWTH-FACTOR; NATURAL-PRODUCT PRESENT; DECREASES TUMOR-GROWTH;
D O I：
10.1097/CEJ.0b013e3282f0c090
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatocellular carcinoma (HCC) is the fifth commonest malignancy worldwide and the incidence is rising. Surgery, including transplantation resection, is currently the most effective treatment for HCC; however, recurrence rates are high and long-term survival is poor. Identifying novel chemopreventive and chemotherapeutic agents and targeting them to patients at high risk of developing HCC or following curative treatment may go some way towards improving prognosis. This review examines current knowledge regarding the chemopreventive and chemotherapeutic potential of phytochemicals in heptocarcinogenesis. Both in-vitro and animal studies demonstrate that several phytochemicals, including curcumin, resveratrol, green tea catechins, oltipraz and silibinin, possess promising chemopreventive and chemotherapeutic properties. Despite this, very few clinical trials have been performed. Problems regarding validation of biomarkers, agent delivery, side effects and patient selection are barriers that need to be overcome to determine the potential of such agents in clinical practice. European Journal of Cancer Prevention 18:13-25 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：13 / 25
页数：13
相关论文
共 203 条
[1]   Protection by the flavonoids myricetin, quercetin, and rutin against hydrogen peroxide-induced DNA damage in Caco-2 and Hep G2 cells [J].
Aherne, SA ;
O'Brien, NM .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1999, 34 (02) :160-166
[2]   MODULATING EFFECTS OF ELLAGIC ACID, VANILLIN AND QUERCETIN IN A RAT MEDIUM-TERM MULTIORGAN CARCINOGENESIS MODEL [J].
AKAGI, K ;
HIROSE, M ;
HOSHIYA, T ;
MIZOGUCHI, Y ;
ITO, N ;
SHIRAI, T .
CANCER LETTERS, 1995, 94 (01) :113-121
[3]  
Bae MK, 2006, ONCOL REP, V15, P1557
[4]  
Bailey G, 1982, Basic Life Sci, V21, P149
[5]  
BAILEY GS, 1987, JNCI-J NATL CANCER I, V78, P931
[6]   A phase II trial of daily perillyl alcohol in patients with advanced ovarian cancer: Eastern Cooperative Oncology Group study E2E96 [J].
Bailey, HH ;
Levy, D ;
Harris, LS ;
Schink, JC ;
Foss, F ;
Beatty, P ;
Wadler, S .
GYNECOLOGIC ONCOLOGY, 2002, 85 (03) :464-468
[7]   Effects of dietary oltipraz and ethoxyquin on aflatoxin B1 biotransformation in non-human primates [J].
Bammler, TK ;
Slone, DH ;
Eaton, DL .
TOXICOLOGICAL SCIENCES, 2000, 54 (01) :30-41
[8]   Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells [J].
Belloir, C. ;
Singh, V. ;
Daurat, C. ;
Siess, M. H. ;
Le Bon, A. M. .
FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (06) :827-834
[9]   Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats [J].
Bergès, R ;
Siess, MH ;
Arnault, I ;
Auger, J ;
Kahane, R ;
Pinnert, MF ;
Vernevaut, MF ;
le Bon, AM .
CARCINOGENESIS, 2004, 25 (10) :1953-1959
[10]  
BOLTON MG, 1993, CANCER RES, V53, P3499
12345678910