Determination of nephrotoxicity and genotoxic potential of silver nanoparticles in Swiss albino mice

被引：12

作者：

Alarifi, Saud ^{[1
]}

Ali, Daoud ^{[1
]}

Al Gurabi, Mohammed A. ^{[1
]}

Alkahtani, Saad ^{[1
]}

机构：

[1] King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi Arabia

来源：

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2017年 / 99卷 / 02期

关键词：

Silver nanoparticles; kidney tissue; histology; apoptosis; DNA damage; IN-VITRO; TOXICITY; NANOMATERIALS; VIVO;

D O I：

10.1080/02772248.2016.1175153

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Silver nanoparticles (AgNPs) possess properties that are important for industrial and medical applications. This study is aimed to investigate intra-peritoneal toxicity of AgNPs at 26, 52 or 78 mg/kg/day for 5days in mice Swiss albino mice. The effects on oxidative stress markers activities of serum superoxide dismutase (SOD) and catalase (CAT), levels of serum glutathione (GSH), apoptosis (TUNEL assay), DNA strand breaks (comet assay) in lymphocytes, as well as histopathological of kidney tissue were determined. AgNPs significantly increased SOD and CAT activities reduced GSH levels. In kidney apoptosis (TUNEL assay) while DNA strand breaks (comet assay) in lymphocytes revealed that AgNPs at concentration 78 mg/kg produced significant apoptosis and DNA damage. AgNPs also produced associated histological renal tissue damage. Evidence suggests that AgNPs-mediated alterations may be attributed to oxidative stress.

引用

页码：294 / 301

页数：8

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