Safety and Activity of the Highly Specific BTK Inhibitor BGB-3111 in Combination with the PD-1 Inhibitor BGB-A317 in Patients with B-Cell Lymphoid Malignancies

被引：0

作者：

Cull, Gavin

Opat, Stephen

Trotman, Judith

Hilger, James

Zhang, Xiaoping

Feng, Shibao

Ro, Sunhee

Huang, Jane

Tam, Constantine S.

机构：

来源：

BLOOD | 2017年 / 130卷

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D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

4057

引用

页数：4

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[21] Phase-I Study of the new B-Cell Lymphoma 2 (BCL2) Inhibitor BGB-11417 as Monotherapy or in Combination with Zanubrutinib (zanu) in Patients (pat) with B-Cell Malignancies: preliminary Data [J].

Stilgenbauer, S. ;

Opat, S. ;

Cheah, C. Y. ;

Lasica, M. ;

Verner, E. ;

Browett, P. J. ;

Chan, H. ;

Soumerai, J. D. ;

Gonzalez, Barca E. ;

Hilger, J. ;

Fang, Y. ;

Simpson, D. ;

Tam, C. S. .

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[22] Efficacy and Safety of PD-1 Inhibitor Plus Rituximab in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma [J].

Qin, Yan ;

He, Xiaohui ;

Yang, Sheng ;

Liu, Peng ;

Zhou, Shengyu ;

Yang, Jianliang ;

Gui, Lin ;

Zhong, Qiaofeng ;

Zhao, Fengyi ;

Shi, Yuankai ;

Jing, Hongmei ;

Zhang, Shiyue ;

Guo, Ruihan ;

Shi, Yuankai .

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[23] Targeted microbubbles with ultrasound irradiation and PD-1 inhibitor to increase antitumor activity in B-cell lymphoma [J].

Zheng, Shiya ;

Song, Dan ;

Jin, Xiaoxiao ;

Zhang, Haijun ;

Aldarouish, Mohanad ;

Chen, Yan ;

Wang, Cailian .

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[24] Investigation of T cell activation by anti-human PD-1 antibodies Nivolumab, Pembrolizumab and BGB-A317 using tumor-infiltrating lymphocytes (TILs) from colorectal cancer and colorectal liver metastasis patients [J].

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Zhang, Tong ;

Fu, Chunyan ;

Zhang, Yanjuan ;

Guo, Amy ;

Zhou, Dongping ;

Zhang, Lianhai ;

Wang, Kun ;

Xing, Baocai ;

Ji, Jiafu ;

Wang, Lai ;

Li, Kang .

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Abou-Alfa, G. ;

Ren, Z. ;

Assenat, E. ;

Cubillo, A. ;

Pluntke, S. ;

Rimassa, L. ;

Ross, P. ;

Wyrwicz, L. ;

Hou, J. ;

Li, C. ;

Wu, J. ;

Ducreux, M. .

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Irie, Takayuki ;

Kashimoto, Shigeki ;

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Sawa, Masaaki .

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Cheah, Chan Yoon ;

Parrondo, Ricardo ;

Thompson, Meghan C. ;

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