Construction and analysis of dysregulated lncRNA-associated ceRNA network in colorectal cancer

被引：25

作者：

Zhu, Yiping ^{[1
,2
]}

Bian, Yinzhu ^{[3
]}

Zhang, Qun ^{[4
]}

Hu, Jing ^{[4
]}

Li, Li ^{[4
]}

Yang, Mi ^{[4
]}

Qian, Hanqing ^{[4
]}

Yu, Lixia ^{[4
]}

Liu, Baorui ^{[1
,4
]}

Qian, Xiaoping ^{[1
,4
]}

机构：

[1] Nanjing Med Univ, Comprehens Canc Ctr, Nanjing Drum Tower Hosp, Clin Coll, Nanjing 210000, Jiangsu, Peoples R China

[2] Wannan Med Coll, Dept Oncol, Yijishan Hosp, Wuhu, Anhui, Peoples R China

[3] First Peoples Hosp Yancheng, Dept Oncol, Yancheng, Jiangsu, Peoples R China

[4] Nanjing Univ, Nanjing Drum Tower Hosp, Ctr Comprehens Canc, Med Sch,Clin Canc Inst, Nanjing, Jiangsu, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 06期

关键词：

bioinformatics analysis; colorectal cancer; competing endogenous RNA; long noncoding RNA; weighted gene corepression analysis; SUBCELLULAR-LOCALIZATION; MESENCHYMAL TRANSITION; TERTIARY STRUCTURE; MESSENGER-RNAS; GENE; PREDICTION; METASTASIS; PROTEINS; SURVIVAL; CDK1;

D O I：

10.1002/jcb.28201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is one of the most frequently diagnosed digestive system cancer. The aim of the present study was to investigate the interactions among messenger RNAs (mRNAs), microRNAs (miRNAs), and long noncoding RNAs (lncRNAs) in CRC to reveal the mechanisms of CRC. Differentially expressed genes (DEGs) were identified from public gene expression data sets. One thousand eighty-one common dysregulated mRNAs in two data sets were identified. Gene function analysis and protein-protein interaction network analysis indicated that these DEGs might play important roles in CRC. LINC00365 was selected through coding- noncoding network analysis and its expression was validated upregulated in 22 paired clinical samples and four CRC cell lines. A competing endogenous RNA network composed of 70 miRNAs, nine mRNAs, and LINC00365 was constructed. Eight of nine mRNAs were validated upregulated in The Cancer Genome Atlas data set. Our results suggested that LINC00365 was an oncogene in CRC and it could regulate the expression of several mRNAs through sponging miRNAs.

引用

页码：9250 / 9263

页数：14

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