Abiotic degradation of antibiotic ionophores

被引：35

作者：

Bohn, Pernille ^{[1
]}

Bak, Soren A. ^{[1
]}

Bjorklund, Erland ^{[1
]}

Krogh, Kristine A. ^{[1
]}

Hansen, Martin ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Hlth & Med Sci, Dept Pharm, Toxicol Laboratoiy Analyt Biosci, DK-2100 Copenhagen, Denmark

来源：

ENVIRONMENTAL POLLUTION | 2013年 / 182卷

关键词：

Ionophore; Degradation; Hydrolysis; Photolysis; LC-MS/MS; VETERINARY PHARMACEUTICALS; LIQUID-CHROMATOGRAPHY; WATER; MONENSIN; FATE; SOIL; SALINOMYCIN; MACROLIDES; TIAMULIN; SORPTION;

D O I：

10.1016/j.envpol.2013.06.040

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Hydrolytic and photolytic degradation were investigated for the ionophore antibiotics lasalocid, monensin, salinomycin, and narasin. The hydrolysis study was carried out by dissolving the ionophores in solutions of pH 4, 7, and 9, followed by incubation at three temperatures of 6, 22, and 28 degrees C for maximum 34 days. Using LC-MS/MS for chemical analysis, lasalocid was not found to hydrolyse in any of the tested environments. Monensin, salinomycin, and narasin were all stable in neutral or alkaline solution but hydrolysed in the solution with a pH of 4. Half-lives at 25 degrees C were calculated to be 13, 0.6, and 0.7 days for monensin, salinomycin, and narasin, respectively. Absorbance spectra from each compound indicated that only lasalocid is degraded by photolysis (half-life below 1 h) due to an absorbance maximum around 303 nm, and monensin, salinomycin, and narasin are resistant to direct photolysis because they absorb light of environmentally irrelevant wavelengths. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：177 / 183

页数：7

共 35 条

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