Genetic diversity of HLA system in a population from Guerrero, Mexico

被引：4

作者：

Juarez-Nicolas, Francisco ^{[1
]}

Barquera, Rodrigo ^{[2
,3
]}

Cesar Martinez-Alvarez, Julio ^{[4
]}

Iraiz Hernandez-Zaragoza, Diana ^{[3
,5
]}

Ortega-Yanez, Andrea ^{[6
]}

Arrieta-Bolanos, Esteban ^{[7
]}

Clayton, Stephen ^{[2
]}

Bravo-Acevedo, Alicia ^{[8
]}

Araceli Arrazola-Garcia, Maria ^{[4
]}

Immel, Alexander ^{[2
,9
]}

Juarez-Barreto, Vicencio ^{[10
]}

Benitez-Arvizu, Gamaliel ^{[11
]}

del Rosario Vega-Martinez, Maria ^{[12
]}

Garcia-Alvarez, Raquel ^{[13
]}

Martinez-Bezies, Virginia ^{[1
]}

Berenice Escutia-Gonzalez, Ariadna ^{[1
]}

Diaz-Lopez, Rosario ^{[14
]}

Ulises Guizar-Lopez, Gregorio ^{[14
]}

Salgado-Galicia, Norma ^{[12
]}

Zuniga, Joaquin ^{[15
,16
]}

Yunis, Edmond J. ^{[17
]}

Bekker-Mendez, Carolina ^{[18
]}

Granados, Julio ^{[19
]}

机构：

[1] Inst Nacl Pediat INP, Mol Immunogenet Lab, Mexico City, DF, Mexico

[2] Max Planck Inst Sci Human Hist MPI SHH, Dept Archaeogenet, Jena, Germany

[3] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[4] Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especialidad UMAE Ctr Med Nacl Si, Hosp Especialidades, HLA Lab,Cent Blood Bank, Mexico City, DF, Mexico

[5] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[6] Univ Nacl Autonoma Mexico, Inst Biotecnol IBT, Dept Dev Genet & Mol Physiol, Cuernavaca, Morelos, Mexico

[7] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[8] Inst Mexicano Seguro Social IMSS, UMAE Hosp Gineco Obstet 4 Luis Castelazo Ayala, Blood Bank, Mexico City, DF, Mexico

[9] Univ Kiel, Univ Hosp, Inst Clin Mol Biol IKMB, Schleswig Holstein, Germany

[10] Hosp Infantil Mexico Dr Federico Gomez, Blood Bank, Mexico City, DF, Mexico

[11] Inst Mexicano Seguro Social IMSS, Unidad Med Alta Especialidad UMAE Ctr Med Nacl Si, Hosp Especialidades, Cent Blood Bank, Mexico City, DF, Mexico

[12] Hosp Cent Sur Alta Especialidad, Mol Biol & Histocompatibil Lab, Petroleos Mexicanos PEMEX, Mexico City, DF, Mexico

[13] Inst Nacl Pediat INP, Res Unit, Pharmacol Lab, Mexico City, DF, Mexico

[14] Hosp Cent Mil, Mol Biol Lab, Secretaria Def Nacl SEDENA, Mexico City, DF, Mexico

[15] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[16] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[17] Dana Farber Canc Inst, Dept Canc Immunol & Virol, 44 Binney St 1234, Boston, MA 02115 USA

[18] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Mexico City, DF, Mexico

[19] Inst Nacl Ciencias Med & Nutr Salvador Zubiran IN, Dept Transplantat, Mexico City, DF, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

关键词：

HLA; Immunogenetics; Population genetics; Guerrero; Admixture; ADMIXTURE;

D O I：

10.1016/j.humimm.2019.05.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 144 Mexicans from the state of Guerrero to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in the state of Guerrero include eight Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in the state of Guerrero are Native American (61.36 +/- 2.69% by ML; 54.17% of Native American haplotypes) and European (35.01 +/- 4.59% ML; 32.29% of European haplotypes), and a relatively low African genetic component (3.63 +/- 2.38% by ML; 5.90% of African haplotypes).

引用

页码：550 / 552

页数：3

共 16 条

[1] Analysis of admixture proportions in seven geographical regions of the state of Guerrero, Mexico [J].

Angel Cahua-Pablo, Jose ;

Cruz, Miguel ;

Vidal Tello-Almaguer, Pedro ;

Carmen del Alarcon-Romero, Luz ;

Juan Parra, Esteban ;

Villerias-Salinas, Salvador ;

Valladares-Salgado, Adan ;

Argelia Tello-Flores, Vianet ;

Mendez-Palacios, Abigail ;

Paola Perez-Macedonio, Claudia ;

Flores-Alfaro, Eugenia .

AMERICAN JOURNAL OF HUMAN BIOLOGY, 2017, 29 (06)

[2]

[Anonymous], 2003, INVESTIGACIONES GEOG, V50, P196

[3]

[Anonymous], 2019, ENCY BRITANNICA

[4] The immunogenetic diversity of the HLA system in Mexico correlates with underlying population genetic structure [J].

Barquera, Rodrigo ;

Iraiz Hernandez-Zaragoza, Diana ;

Bravo-Acevedo, Alicia ;

Arrieta-Bolanos, Esteban ;

Clayton, Stephen ;

Acuna-Alonzo, Victor ;

Cesar Martinez-Alvarez, Julio ;

Lopez-Gil, Concepcion ;

Adalid-Sainz, Carmen ;

del Rosario Vega-Martinez, Maria ;

Escobedo-Ruiz, Araceli ;

Dolores Juarez-Cortes, Eva ;

Immel, Alexander ;

Pacheco-Ubaldo, Hanna ;

Gonzalez-Medina, Liliana ;

Lona-Sanchez, Abraham ;

Lara-Riegos, Julio ;

Guadalupe de Jesus Sanchez-Fernandez, Maria ;

Diaz-Lopez, Rosario ;

Ulises Guizar-Lopez, Gregorio ;

Elizabeth Medina-Escobedo, Carolina ;

Araceli Arrazola-Garcia, Maria ;

Daniel Montiel-Hernandez, Gustavo ;

Hernandez-Hernandez, Ofelia ;

del Rocio Ramos-de la Cruz, Flor ;

Juarez-Nicolas, Francisco ;

Arturo Pantoja-Torres, Jorge ;

Jesus Rodriguez-Munguia, Tirzo ;

Juarez-Barreto, Vicencio ;

Delgado-Aguirre, Hector ;

Berenice Escutia-Gonzalez, Ariadna ;

Gone-Vazquez, Isis ;

Benitez-Arvizu, Gamaliel ;

Paulina Arellano-Prado, Francia ;

Eduardo Garcia-Arias, Victor ;

Estefania Rodriguez-Lopez, Marla ;

Mendez-Mani, Patricia ;

Garcia-Alvarez, Raquel ;

del Rocio Gonzalez-Martinez, Marisela ;

Aquino-Rubio, Guadalupe ;

Escareno-Montiel, Nestor ;

Veronica Vazquez-Castillo, Tannya ;

Guadalupe Uribe-Duarte, Maria ;

de Jesus Ruiz-Corral, Maria ;

Ortega-Yanez, Andrea ;

Bernal-Felipe, Natalia ;

Gomez-Navarro, Benjamin ;

Jerico Arriaga-Perea, Agustin ;

Martinez-Bezies, Virginia ;

Maria Macias-Medrano, Rosa .

HUMAN IMMUNOLOGY, 2020, 81 (09) :461-474

[5]

Carrillo R, 2014, ASIADEMICA REV U EST, V3, P81

[6]

Gorenstein S.S., 2008, CAMBRIDGE HIST NAT 1, VII, P318

[7] OLMEC CAVE PAINTINGS - DISCOVERY FROM GUERRERO MEXICO [J].

GROVE, DC .

SCIENCE, 1969, 164 (3878) :421-&

[8]

Instituto Nacional de Estadistica y Geografia, 2011, CENS POBL VIV 2010

[9] Maternal admixture and population structure in Mexican-Mestizos based on mtDNA haplogroups [J].

Martinez-Cortes, Gabriela ;

Salazar-Flores, Joel ;

Haro-Guerrero, Javier ;

Rubi-Castellanos, Rodrigo ;

Velarde-Felix, Jesus S. ;

Munoz-Valle, Jose F. ;

Lopez-Casamichana, Mavil ;

Carrillo-Tapia, Eduardo ;

Canseco-Avila, Luis M. ;

Bravi, Claudio M. ;

Lopez-Armenta, Mauro ;

Rangel-Villalobos, Hector .

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2013, 151 (04) :526-537

[10] Admixture and population structure in Mexican-Mestizos based on paternal lineages [J].

Martinez-Cortes, Gabriela ;

Salazar-Flores, Joel ;

Gabriela Fernandez-Rodriguez, Laura ;

Rubi-Castellanos, Rodrigo ;

Rodriguez-Loya, Carmen ;

Salvador Velarde-Felix, Jesus ;

Franciso Munoz-Valle, Jose ;

Parra-Rojas, Isela ;

Rangel-Villalobos, Hector .

JOURNAL OF HUMAN GENETICS, 2012, 57 (09) :568-574

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