The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients

被引：301

作者：

Ward, Nicholas S. ^{[1
]}

Casserly, Brian ^{[1
]}

Ayala, Alfred ^{[2
]}

机构：

[1] Brown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA

[2] Brown Univ, Warren Alpert Med Sch, Dept Surg, Div Surg Res, Providence, RI 02912 USA

来源：

CLINICS IN CHEST MEDICINE | 2008年 / 29卷 / 04期

关键词：

Sepsis; Compensatory anti-inflammatory response syndrome; Anergy; Systemic inflammatory response syndrome; Anti-inflammatory; Human leukocyte antigen;

D O I：

10.1016/j.ccm.2008.06.010

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.

引用

页码：617 / +

页数：10

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