The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients
被引:295
作者:
Ward, Nicholas S.
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Brown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA
Ward, Nicholas S.
[1
]
Casserly, Brian
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Brown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA
Casserly, Brian
[1
]
Ayala, Alfred
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Brown Univ, Warren Alpert Med Sch, Dept Surg, Div Surg Res, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA
Ayala, Alfred
[2
]
机构:
[1] Brown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA
[2] Brown Univ, Warren Alpert Med Sch, Dept Surg, Div Surg Res, Providence, RI 02912 USA
Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.