The Compensatory Anti-inflammatory Response Syndrome (CARS) in Critically Ill Patients

被引:295
作者
Ward, Nicholas S. [1 ]
Casserly, Brian [1 ]
Ayala, Alfred [2 ]
机构
[1] Brown Univ, Warren Alpert Med Sch, Div Pulm Crit Care & Sleep Med, Providence, RI 02912 USA
[2] Brown Univ, Warren Alpert Med Sch, Dept Surg, Div Surg Res, Providence, RI 02912 USA
关键词
Sepsis; Compensatory anti-inflammatory response syndrome; Anergy; Systemic inflammatory response syndrome; Anti-inflammatory; Human leukocyte antigen;
D O I
10.1016/j.ccm.2008.06.010
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.
引用
收藏
页码:617 / +
页数:10
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