Sinusoidal obstruction syndrome

被引:28
作者
Ledinghen, Victor de [1 ,2 ]
Villate, Alban [3 ]
Robin, Marie [4 ]
Decraecker, Marie [1 ,2 ]
Valla, Dominique [5 ,6 ]
Hillaire, Sophie [8 ]
Hernandez-Gea, Virginia [9 ,10 ]
Dutheil, Daniell [11 ]
Bureau, Christophe [12 ]
Plessier, Aurelie [5 ,6 ,7 ]
机构
[1] Univ Hosp Bordeaux, Dept Hepatol, Haut Leveque Hosp, Ave Magellan, F-33600 Pessac, France
[2] Univ Hosp Bordeaux, INSERM U1053, Haut Leveque Hosp, Ave Magellan, F-33600 Pessac, France
[3] Univ Hosp Tours, Bretonneau Hosp, Dept Hematol, 2 Blvd Tonnelle, F-37000 Tours, France
[4] St Louis Hosp, AP HP, Dept Hematol, 1 Ave Claude Vellefaux, F-75475 Paris 10, France
[5] Beaujon Hosp, AP HP, Dept Hepatol, DHU Unity, 100 Blvd Gen Leclerc, F-92118 Clichy, France
[6] St Antoine Hosp, AP HP, French Network Rare Liver Dis FILFOIE, 184 Rue Faubourg St Antoine, F-75012 Paris, France
[7] European Reference Network ERN Rare Liver, Reference Ctr Vasc Liver Dis, Clichy, France
[8] Foch Hosp, Dept Internal Med, 40 Rue Worth, F-92150 Suresnes, France
[9] Univ Barcelona, Barcelona Hepat Hemodynam Lab, Liver Unit, Hosp Clin,Inst Invest Biomed August Pi & Sunyer I, Barcelona, Spain
[10] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Hlth Care Provider European Reference Network onR, Barcelona, Spain
[11] Beaujon Hosp, Dept Hepatol, Liver Vasc Dis Patient Org AMVF, 100 Blvd Gen Leclerc, F-92118 Clichy, France
[12] Univ Hosp Toulouse, Dept Gastroenterol & Hepatol, Rangueil Hosp, 1 Ave Prof Jean Poulhes, F-31400 Toulouse, France
关键词
Sinusoidal obstruction syndrome; Hepatic Veno-occlusive disease; Hematopoietic stem cells transplant; HEPATIC VENOOCCLUSIVE DISEASE; STEM-CELL TRANSPLANTATION; OXALIPLATIN-BASED CHEMOTHERAPY; MARROW TRANSPLANTATION; LIVER; DEFIBROTIDE; DIAGNOSIS; PHASE-3; LESIONS;
D O I
10.1016/j.clinre.2020.03.019
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Sinusoidal obstruction syndrome (SOS), previously known as veno-occlusive disease, is characterized by concentric and non-thrombotic obstruction of the sinusoid and central vein lumen with no identified primitive or thrombotic hepatic vein lesions. The initial lesion is a result of endothelial denudation, corresponding to the migration of damaged sinusoidal cells to the central veins of the hepatic lobules, leading to sinusoidal and veno-occlusive congestive obstruction. SOS may be associated with other lesions such as centrilobular perisinusoidal fibrosis, peliosis, or nodular regenerative hyperplasia. The first cases of SOS were documented in 1920 in South Africa, after ingestion of food sources contaminated by pyrrolizidine alkaloids. SOS is a well-known complication of hematopoietic stem cell transplantation (HSCT). Numerous toxins and drugs have been associated with SOS, mainly chemotherapies and immunosuppressive therapies, as well as total body or liver irradiation and ABO mismatch platelet transfusion. The pathogenesis of this entity remains unknown. (C) 2020 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:480 / 485
页数:6
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