Evidence for discrete stages of human natural killer cell differentiation in vivo

被引：322

作者：

Freud, AG

Yokohama, A

Becknell, B

Lee, MT

Mao, HYC

Ferketich, AK

Caligiuri, MA ^{[1
]}

机构：

[1] Ohio State Univ, Integrated Biomed Sci Grad Program, Coll Med & Publ Hlth, Columbus, OH 43210 USA

[2] Ohio State Univ, Med Scientist Program, Coll Med & Publ Hlth, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Coll Med & Publ Hlth, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Epidemiol & Biometr, Coll Med & Publ Hlth, Columbus, OH 43210 USA

[5] Ohio State Univ, Div Hematol Oncol, Coll Med & Publ Hlth, Dept Internal Med, Columbus, OH 43210 USA

[6] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 04期

关键词：

D O I：

10.1084/jem.20052507

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human natural killer (NK) cells originate from CD34(+) hematopoietic progenitor cells, but the discrete stages of NK cell differentiation in vivo have not been elucidated. We identify and functionally characterize, from human lymph nodes and tonsils, four NK cell developmental intermediates spanning the continuum of differentiation from a CD34(+) NK cell progenitor to a functionally mature NK cell. Analyses of each intermediate stage for CD34, CD117, and CD94 cell surface expression, lineage differentiation potentials, capacity for cytokine production and natural cytotoxicity, and ETS-1, GATA-3, and T-BET expression provide evidence for a new model of human NK cell differentiation in secondary lymphoid tissues.

引用

页码：1033 / 1043

页数：11

共 33 条

[1] The Ets-1 transcription factor is required for the development of natural killer cells in mice [J].