The ubiquitin system

被引：516

作者：

Varshavsky, A

机构：

[1] Division of Biology, California Institute of Technology, Pasadena

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 10期

关键词：

D O I：

10.1016/S0968-0004(97)01122-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.

引用

页码：383 / 387

页数：5

共 70 条

[31] CONTROL OF CELL FATE BY A DEUBIQUITINATING ENZYME ENCODED BY THE FAT FACETS GENE
HUANG, YZ
BAKER, RT
FISCHERVIZE, JA
[J]. SCIENCE, 1995, 270 (5243) : 1828 - 1831
[32] THE YEAST DNA-REPAIR GENE RAD6 ENCODES A UBIQUITIN-CONJUGATING ENZYME
JENTSCH, S
MCGRATH, JP
VARSHAVSKY, A
[J]. NATURE, 1987, 329 (6135) : 131 - 134
[33] SELECTIVE PROTEIN-DEGRADATION - A JOURNEYS END WITHIN THE PROTEASOME
JENTSCH, S
SCHLENKER, S
[J]. CELL, 1995, 82 (06) : 881 - 884
[34] THE UBIQUITIN-CONJUGATION SYSTEM
JENTSCH, S
[J]. ANNUAL REVIEW OF GENETICS, 1992, 26 : 179 - 207
[35] CIS-TRANS RECOGNITION AND SUBUNIT-SPECIFIC DEGRADATION OF SHORT-LIVED PROTEINS
JOHNSON, ES
GONDA, DK
VARSHAVSKY, A
[J]. NATURE, 1990, 346 (6281) : 287 - 291
[36] A PROTEOLYTIC PATHWAY THAT RECOGNIZES UBIQUITIN AS A DEGRADATION SIGNAL
JOHNSON, ES
MA, PCM
OTA, IM
VARSHAVSKY, A
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (29) : 17442 - 17456
[37] How proteolysis drives the cell cycle
King, RW
Deshaies, RJ
Peters, JM
Kirschner, MW
[J]. SCIENCE, 1996, 274 (5293) : 1652 - 1659
[38] The linker region of this ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein
Kolling, R
Losko, S
[J]. EMBO JOURNAL, 1997, 16 (09) : 2251 - 2261
[39] REGULATED DEGRADATION OF THE TRANSCRIPTION FACTOR GCN4
KORNITZER, D
RABOY, B
KULKA, RG
FINK, GR
[J]. EMBO JOURNAL, 1994, 13 (24) : 6021 - 6030
[40] Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome
Lam, YA
Xu, W
DeMartino, GN
Cohen, RE
[J]. NATURE, 1997, 385 (6618) : 737 - 740

← 1 2 3 4 5 6 7 →