The ubiquitin system

被引：516
作者：
Varshavsky, A
机构：
[1] Division of Biology, California Institute of Technology, Pasadena
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 10期
关键词：
D O I：
10.1016/S0968-0004(97)01122-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Eukaryotes contain a highly conserved multi-enzyme system that covalently links ubiquitin to a variety of intracellular proteins that bear degradation signals recognized by this system. The resulting ubiquitin-protein conjugates are degraded by the 26S proteasome, a large ATP-dependent protease. Pathways that involve ubiquitin underlie a multitude of processes, including cell differentiation, the cell cycle and responses to stress.
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页码：383 / 387
页数：5
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