Trilineage Hematopoiesis Induced by Low-dose Eltrombopag in a Patient With Fanconi Anemia can be Used as a Bridge to Hematopoietic Stem Cell Transplant

被引：2

作者：

Gupta, Ashish ^{[1
]}

Palassery, Rasmi ^{[3
]}

Meyerson, Howard ^{[2
]}

Ahuja, Sanjay ^{[1
]}

Matloub, Yousif ^{[1
]}

机构：

[1] Case Western Univ, Rainbow Babies & Childrens Hosp, Div Pediat Hematol Oncol, 11100 Euclid Ave,RBC 6054, Cleveland, OH 44106 USA

[2] Univ Hosp Cleveland Med Ctr, Div Pathol, Cleveland, OH USA

[3] HCG MSR Canc Ctr, Bangalore, Karnataka, India

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2019年 / 41卷 / 03期

关键词：

eltrombopag; trilineage hematopoiesis; Fanconi anemia; BONE-MARROW-TRANSPLANTATION; APLASTIC-ANEMIA; OXYMETHOLONE TREATMENT; SIBLING DONOR; CYCLOPHOSPHAMIDE; THROMBOCYTOPENIA; IRRADIATION; REGISTRY;

D O I：

10.1097/MPH.0000000000001168

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fanconi anemia (FA) is an autosomal recessive, progressive bone marrow failure disorder characterized by congenital defects and marked cancer predisposition. Hematopoietic stem cell transplant is the therapy of choice for FA patients with progressive pancytopenia. These patients receive multiple transfusions for cytopenias. Oxymetholone has been used with variable success to improve cytopenias. Eltrombopag has been shown to induce bilineage or trilineage hematopoiesis in aplastic anemia and patients with myelodysplastic marrow. We report a case of FA where eltrombopag in conjunction with oxymetholone induced trilineage hematopoiesis and eliminated transfusion requirement before transplant, thereby enhancing favorable outcome after hematopoietic stem cell transplant.

引用

页码：229 / 232

页数：4