Experimental Models of Hemorrhagic Shock: A Review

被引：74

作者：

Fulop, A. ^{[1
]}

Turoczi, Z. ^{[1
]}

Garbaisz, D. ^{[1
]}

Harsanyi, L. ^{[1
]}

Szijarto, A. ^{[1
]}

机构：

[1] Semmelweis Univ, Dept Surg 1, Budapest, Hungary

来源：

EUROPEAN SURGICAL RESEARCH | 2013年 / 50卷 / 02期

关键词：

Animal model; Experimental model; Hemorrhage; Hemorrhagic shock; Shock; SMALL-VOLUME RESUSCITATION; TRAUMATIC BRAIN-INJURY; HYPERTONIC SALINE; FLUID RESUSCITATION; UNCONTROLLED HEMORRHAGE; CANINE MODEL; LACTATED RINGERS; IMMUNE-RESPONSES; BLOOD-LOSS; INFLAMMATORY RESPONSE;

D O I：

10.1159/000348808

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Massive blood loss leading to hypovolemic shock is still a life-threatening situation. Recently, a great number of investigations have been conducted in order to understand the pathophysiological and immunological changes taking place during shock and to develop treatment strategies. These preclinical trials are based on animal studies. Although a wide spectrum of species and experimental models are available to researchers, it is rather difficult to create an ideal animal model to study hemorrhagic shock. A major challenge for investigators is the generation of a system which is simple, easily reproducible and standardized, while being an accurate replica of the clinical situation. The goal of this review is to summarize the current experimental models of hemorrhagic shock, highlighting their advantages and disadvantages to help researchers find the most appropriate model for their own experiments on hypovolemic shock. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：57 / 70

页数：14

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