Goose RIG-I functions in innate immunity against Newcastle disease virus infections

被引：65
|
作者：
Sun, Yingjie [1 ]
Ding, Na [1 ]
Ding, Siyu Serena [2 ]
Yu, Shengqing [1 ]
Meng, Chunhun [1 ]
Chen, Hongjun [1 ]
Qiu, Xusheng [1 ]
Zhang, Shilei [1 ]
Yu, Yang [1 ]
Zhan, Yuan [1 ]
Ding, Chan [1 ]
机构：
[1] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China
[2] Univ Oxford, Dept Biochem, Oxford OX1 4AJ, England
来源：
MOLECULAR IMMUNOLOGY | 2013年 / 53卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Goose RIG-I gene; Newcastle disease virus (NDV); Innate immunity; DOUBLE-STRANDED-RNA; ANTIVIRAL RESPONSES; 5'-TRIPHOSPHATE RNA; INFLUENZA; PROTEIN; RECOGNITION; ACTIVATION; RECEPTORS; HELICASES; CHICKENS;
D O I：
10.1016/j.molimm.2012.08.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mammalian retinoic acid-inducible gene I (RIG-I) is a chief antiviral gene sensing viral RNA molecules including Newcastle disease virus (NDV). In this study, goose RIG-I gene (gRIG-I) was identified. The 2805 bp-long gene encodes a gRIG-I protein that exhibits 93.8% amino acid identity to duck RIG-I. DF-1 chicken fibroblast cells transfected with full-length of gRIG-I or CARD domain of gRIG-I plasmids respond significantly to the agonist of 21-mer 5'ppp RNA, evident through enhancement of IFN-beta promoter activity. Goose RIG-I transfected 293T/17 cells were then tested for the response to NDV infection, resulting in up-regulated activity of IFN-beta promoter, and mRNA levels of IRF-3 and IFIT1, but decreased virus titer. Similar results were obtained in transfected DF-1 chicken fibroblast cells and goose embryo fibroblast cells in response to NDV infections Animal experiments further support a role of gRIG-I in goose innate immunity against NDV infections by showing increased gRIG-I mRNA levels and decreased virus titer in geese lung and air sac post-infection. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：321 / 327
页数：7
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