Distribution of neurotrophin and TrK receptor-like immunoreactivity in the adrenal gland of birds

被引：3

作者：

Arcamone, N ^{[1
]}

Lucini, C ^{[1
]}

Maruccio, L ^{[1
]}

Castaldo, L ^{[1
]}

Gargiulo, G ^{[1
]}

De Girolamo, P ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Strutture Funz & Tecnol Biol, I-80137 Naples, Italy

来源：

MICROSCOPY RESEARCH AND TECHNIQUE | 2006年 / 69卷 / 02期

关键词：

neurotrophins; neurotrophin receptors; adrenal gland; birds;

D O I：

10.1002/jemt.20273

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The occurrence and localization of neurotrophins and their specific TrK receptor-like proteins in the adrenal gland of chicken, duck and ostrich were examined by immunohistochemical methods. In all species studied NGF-, TrK A- and TrK C-like immunoreactivity was observed in neurons and fibers of adrenal ganglia. Thin TrK A- and TrK C-like immunoreactive fibers were also observed among chromaffin cells. NT-3-like immunoreactivity was detected in chromaffin cells as revealed by the double immunolabelings NT-3/chromogranin A and NT-3/D beta H. The interrenal tissue never showed IR to any neurotrophins and TrK tested, and none of the adrenal structures displayed immunoreactivity to BDNF and TrK B. Double immunolabelings NGF/ TrK A, NGF/TrK C and TrK A/TrK C showed colocalization in some neurons and fibers in adrenal ganglia. In adrenal glands of the species studied, the distribution of neurotrophins and TrK receptors could suggest an involvement of NT-3 on neuronal populations innervating adrenal ganglia by means of its high affinity receptor TrK C and low affinity receptor TrK A. In addition, NGF could be utilized by neuronal populations of adrenal ganglia through its preferential receptor TrK A by an autocrine or paracrine modality of action.

引用

页码：130 / 137

页数：8

共 23 条

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