DRESS syndrome;
vancomycin;
drug rash;
drug hypersensitivity;
eosinophilia;
D O I:
10.1159/000142729
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Background: DRESS syndrome (drug rash with eosinophilia and systemic symptoms) is a hypersensitivity reaction with skin rashes, eosinophilia, fever, lymph node enlargement and internal organ involvement. Case Report: A 60-year-old diabetic woman was hospitalized at the University Hospitals of Geneva for mid-leg amputation due to peripheral arterial occlusive disease. No drug allergy was reported. Because of a wound infection by methicillin-resistant Staphylococcus aureus, treatment with vancomycin (2 g/day) in continuous perfusion was initiated. Approximately 2 weeks later, she developed a toxidermia with fever, a progressive maculopapular skin rash, eosinophilia and acute renal insufficiency. The skin biopsy revealed a necrosis with lymphocytic and eosinophilic infiltrations, supporting the suspicion of DRESS syndrome. A cure was achieved by the withdrawal of vancomycin and the administration of methylprednisolone (1 g/day), antihistaminics and topical mometasone, without the introduction of other antibiotics. Conclusion: Vancomycin can be a cause of DRESS syndrome. A high index of suspicion is warranted in order not to miss this potentially lethal disease. Copyright (C) 2008 S. Karger AG, Basel.
机构:
Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, FranceUniv Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Bouaziz, J-D
;
Valeyrie-Allanore, L.
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机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Valeyrie-Allanore, L.
;
Damak, H.
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机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Damak, H.
;
Faure, H.
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机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Faure, H.
;
Marinho, E.
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h-index: 0
机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Marinho, E.
;
Regnier, B.
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机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
机构:
Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, FranceUniv Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Bouaziz, J-D
;
Valeyrie-Allanore, L.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Valeyrie-Allanore, L.
;
Damak, H.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Damak, H.
;
Faure, H.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Faure, H.
;
Marinho, E.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France
Marinho, E.
;
Regnier, B.
论文数: 0引用数: 0
h-index: 0
机构:Univ Paris 07, Hop Bichat Claude Bernard, Dept Intens Care Unit, Paris, France