Monocyte and Macrophage Heterogeneity in the Heart

被引：294
作者：
Nahrendorf, Matthias
Swirski, Filip K.
机构：
[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
来源：
CIRCULATION RESEARCH | 2013年 / 112卷 / 12期
基金：
美国国家卫生研究院;
关键词：
healing; heart failure; macrophages; monocytes; myocardial infarction; ACUTE MYOCARDIAL-INFARCTION; GENE-EXPRESSION PROFILES; STEM-CELL NICHE; INFLAMMATORY MONOCYTES; BONE-MARROW; CARDIOVASCULAR EVENTS; SPLENIC RESERVOIR; PROGENITOR CELLS; DENDRITIC CELLS; IRON-OXIDE;
D O I：
10.1161/CIRCRESAHA.113.300890
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Monocytes and macrophages are innate immune cells that reside and accumulate in the healthy and injured heart. The cells and their subsets pursue distinct functions in steady-state and disease, and their tenure may range between hours and months. Some subsets are highly inflammatory, whereas others support tissue repair. This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart.
引用
收藏
页码：1624 / 1633
页数：10
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