11C-carbonylation reactions using gas-liquid segmented microfluidics

被引：19
作者：
Dahl, Kenneth [1 ]
Schou, Magnus [2 ]
Ulin, Johan [3 ]
Sjoberg, Carl-Olof [3 ]
Farde, Lars [1 ,2 ]
Halldin, Christer [1 ]
机构：
[1] Karolinska Inst, Karolinska Hosp, Dept Clin Neurosci, Ctr Psychiat Res, S-17176 Stockholm, Sweden
[2] Karolinska Inst, Dept Clin Neurosci, AstraZeneca Translat Sci Ctr, S-17176 Stockholm, Sweden
[3] Bencar AB, S-75183 Uppsala, Sweden
来源：
RSC ADVANCES | 2015年 / 5卷 / 108期
关键词：
CARBONYLATION REACTIONS; LABELING CHEMISTRY; FLOW; REACTOR; PET; PRESSURE; COMPLEXES; MONOXIDE;
D O I：
10.1039/c5ra20646d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel gas-liquid segmented microfluidic platform has been developed. The Pd-mediated C-11-carbonylation reaction proceeds smoothly on this platform and good to excellent radiochemical conversions (RCC) were observed. Twelve compounds were successfully radiolabelled using this novel technology, including the well established D-2 receptor radioligands [C-11]raclopride and [C-11]FLB 457.
引用
收藏
页码：88886 / 88889
页数：4
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