The effect of Glutathione-S-transferases in the susceptibility to bladder cancer

Urinary bladder cancer is a quite common cancer type in men and women all over the world. Genetic polymorphisms of xenobiotic-metabolizing enzymes could increase individual susceptibility to various cancer types. The aim of our study is to evaluate the rate of these polymorphisms in a group of patients from Central Anatolia. Our study subjects consist of 65 men with histopathologically confirmed bladder TCC and 70 cancer-free control subjects. Restriction fragment length polymorphism (RFLP) method was used for the detection of polymorphisms of GSTT1 and GSTM1. There was no association between bladder cancer and GSTM1 polymorphism (ORs = 0.64, 95 % CI = 0.32-1.29), but the probability of bladder cancer in patients with GSTT1 null genotype (67.9 %), was significantly higher from the probability of bladder cancer with GSTT1 normal genotype (43.0 %) statistically (ORs = 2.8, 95 % CI = 1.16-6.75). Polymorphisms of these genes have been assessed to evaluate the relative risk of various cancers. Our intention is to continue this study with larger series of bladder cancer patients in a group of Turkish population from Central Anatolia.