Autophagy in Prostate Cancer and Androgen Suppression Therapy

被引：39

作者：

Ziparo, Elio ^{[1
]}

Petrungaro, Simonetta ^{[1
]}

Marini, Elettra Sara ^{[1
]}

Starace, Donatella ^{[1
]}

Conti, Silvia ^{[1
]}

Facchiano, Antonio ^{[2
]}

Filippini, Antonio ^{[1
]}

Giampietri, Claudia ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, DAHFMO,Sect Histol & Med Embryol, I-00161 Rome, Italy

[2] Ist Dermopat Immacolata, Lab Appl Dermatol, IDI IRCCS, I-00167 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 06期

关键词：

autophagy; apoptosis; prostate cancer; androgen deprivation therapy; ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR-BETA; TGF-BETA; TARGETING AUTOPHAGY; DEPRIVATION THERAPY; CELL-DEATH; TUMOR; APOPTOSIS; PROGRESSION; INHIBITION;

D O I：

10.3390/ijms140612090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.

引用

页码：12090 / 12106

页数：17

共 78 条

[31] Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression:: DR5 and caspase 8 are key players [J].