IGM-7354, AN ANTI-PD-L1/IL-15 IGM IMMUNOCYTOKINE, ACTIVATES AND EXPANDS NK CELLS AND EFFECTOR MEMORY CD8+ T CELLS IN VIVO

被引：0

作者：

Desbois, Melanie ^{[1
]}

Giffon, Thierry ^{[1
]}

Yakkundi, Poonam ^{[1
]}

Pandey, Sivani ^{[1
]}

Rosete, Rodnie ^{[1
]}

Machado, Daniel ^{[1
]}

Manlusoc, Marigold ^{[1
]}

Calhoun, Susan ^{[1
]}

Kothambawala, Tasnim ^{[1
]}

Ananta, Jey ^{[1
]}

Koyama, Kristina ^{[1
]}

Cao, Yuan ^{[1
]}

Ng, Dean ^{[1
]}

Miranda-Katz, Tomas ^{[1
]}

Saini, Avneesh ^{[1
]}

Jain, Abhinav ^{[1
]}

Yue, Hongjun ^{[1
]}

Cai, Yang ^{[1
]}

Oyasu, Miho ^{[1
]}

Bogaert, Liz ^{[1
]}

Funke, Roel ^{[1
]}

Hernandez, Genevive ^{[1
]}

Nagata, Denise ^{[1
]}

Leabman, Maya ^{[1
]}

Humke, Eric ^{[1
]}

Carroll, Stephen ^{[1
]}

Wang, Beatrice ^{[1
]}

Keyt, Bruce ^{[1
]}

Sinclair, Angus ^{[1
]}

Kotturi, Maya ^{[1
]}

机构：

[1] IGM Biosci Inc, Mountain View, CA USA

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2022年 / 10卷

关键词：

D O I：

10.1136/jitc-2022-SITC2022.1215

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1215

引用

页码：A1260 / A1260

页数：1

共 50 条

[41] CD8α+ Dendritic Cell Trans Presentation of IL-15 to Naive CD8+ T Cells Produces Antigen-Inexperienced T Cells in the Periphery with Memory Phenotype and Function
Sosinowski, Tomasz
White, Jason T.
Cross, Eric W.
Haluszczak, Catherine
Marrack, Philippa
Gapin, Laurent
Kedl, Ross M.
JOURNAL OF IMMUNOLOGY, 2013, 190 (05) : 1936 - 1947
[42] Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1
Hogg, A. E.
Bowick, G. C.
Herzog, N. K.
Cloyd, M. W.
Endsley, J. J.
JOURNAL OF LEUKOCYTE BIOLOGY, 2009, 86 (05) : 1191 - 1203
[43] IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells
Liu, KB
Catalfamo, M
Li, Y
Henkart, PA
Weng, NP
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (09) : 6192 - 6197
[44] Difference in immunohistochemical findings among anti-PD-L1 antibodies and their relationships with CD4+ and CD8+ T cells in Japanese melanoma patients
Daisuke Yoneta
Junji Kato
Takafumi Kamiya
Kohei Horimoto
Sayuri Sato
Masahide Sawada
Tomoyuki Minowa
Tokimasa Hida
Shintaro Sugita
Hisashi Uhara
International Journal of Clinical Oncology, 2022, 27 : 1364 - 1371
[45] IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists
Desbois, Melanie
Le Vu, Pauline
Coutzac, Clelia
Marcheteau, Elie
Beal, Coralie
Terme, Magali
Gey, Alain
Morisseau, Sebastien
Teppaz, Geraldine
Boselli, Lisa
Jacques, Yannick
Bechard, David
Tartour, Eric
Cassard, Lydie
Chaput, Nathalie
JOURNAL OF IMMUNOLOGY, 2016, 197 (01) : 168 - 178
[46] Effects of Anti-PD-L1 or IL-15/IL-15Ra-Fc Complex Treatment on CD4-independent CD8+T Cell-Mediated Skin Allograft Rejection
Elzein, Steven
Su, Xiaojun
Zhou, Dawei
Sun, Si
Strahs, Samson Hennessy-
Minze, Laurie
Xiao, Xiang
Li, Xian
AMERICAN JOURNAL OF TRANSPLANTATION, 2025, 25 (01)
[47] IL-15, in synergy with RAE-1ε, stimulates TCR-independent proliferation and activation of CD8+ T cells
Qian, Li
Zhang, Yue
Pan, Xin-Yuan
Ji, Ming-Chun
Gong, Wei-Juan
Tian, Fang
ONCOLOGY LETTERS, 2012, 3 (02) : 472 - 476
[48] The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming
Xiaofei Zhou
Jiayi Yu
Xuhong Cheng
Baoyu Zhao
Ganiraju C. Manyam
Li Zhang
Kimberly Schluns
Pingwei Li
Jing Wang
Shao-Cong Sun
Nature Immunology, 2019, 20 : 879 - 889
[49] Human CD8+ CD28- T Cells Driven In Vitro by IL-15 Suppress in Allo-Specific Manner Partially through PD-1: PD-L1 Pathway.
Feng, F.
Liu, G.
Zhu, P.
Zhu, M.
Lu, X.
Liu, J.
Luo, X.
Liu, Y.
Yu, Y.
AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 : 616 - 616
[50] CD8+ T Cells Sabotage Their Own Memory Potential through IFN-γ-Dependent Modification of the IL-12/IL-15 Receptor α Axis on Dendritic Cells
Kohlhapp, Frederick J.
Zloza, Andrew
O'Sullivan, Jeremy A.
Moore, Tamson V.
Lacek, Andrew T.
Jagoda, Michael C.
McCracken, James
Cole, David J.
Guevara-Patino, Jose A.
JOURNAL OF IMMUNOLOGY, 2012, 188 (08) : 3639 - 3647

← 1 2 3 4 5 →