Thirst regulates motivated behavior through modulation of brainwide neural population dynamics

被引：214

作者：

Allen, William E. ^{[1
,2
,3
]}

Chen, Michael Z. ^{[1
,2
]}

Pichamoorthy, Nandini ^{[1
]}

Tien, Rebecca H. ^{[1
]}

Pachitariu, Marius ^{[4
]}

Luo, Liqun ^{[2
,5
]}

Deisseroth, Karl ^{[1
,5
,6
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Neurosci Grad Program, Stanford, CA 94305 USA

[4] Janelia Res Campus, Ashburn, VA 20147 USA

[5] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

来源：

SCIENCE | 2019年 / 364卷 / 6437期

关键词：

FOOD CUE RESPONSES; LATERAL HYPOTHALAMUS; TRANSIENT DYNAMICS; NEURONAL DYNAMICS; ACTIVITY PATTERNS; CORTEX; CIRCUITS; HUNGER; REPRESENTATIONS; MONKEY;

D O I：

10.1126/science.aav3932

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from similar to 24,000 neurons in 34 brain regions during thirst-motivated choice behavior in 21 mice as they consumed water and became sated. Water-predicting sensory cues elicited activity that rapidly spread throughout the brain of thirsty animals. These dynamics were gated by a brainwide mode of population activity that encoded motivational state. After satiation, focal optogenetic activation of hypothalamic thirst-sensing neurons returned global activity to the pre-satiation state. Thus, motivational states specify initial conditions that determine how a brainwide dynamical system transforms sensory input into behavioral output.

引用

页码：253 / +

页数：40

共 55 条

[1] Brain-wide neuronal dynamics during motor adaptation in zebrafish [J].