Redox-Activated Manganese-Based MR Contrast Agent

被引：158

作者：

Loving, Galen S. ^{[1
]}

Mukherjee, Shreya ^{[1
]}

Caravan, Peter ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, AA Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 12期

关键词：

THIOL/DISULFIDE REDOX; COMPLEXES; CELL; HYPOXIA; BINDING; THIOLS; CANCER; STATE; PET;

D O I：

10.1021/ja312610j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report a simple Mn coordination complex with utility as a redox-sensitive MR probe. The HBET ligand stabilizes both the Mn2+ and Mn3+ oxidation states. In the presence of glutathione (GSH), low relaxivity Mn-III-HBET is converted to high relaxivity Mn-II-HBET with a 3-fold increase in relaxivity, and concomitant increase in MR signal. Alternately, hydrogen peroxide can convert Mn-II-HBET to Mn-III-HBET with a reduction in MR signal.

引用

收藏

页码：4620 / 4623

页数：4

相关论文

共 35 条

[1] Relaxometric evaluation of novel manganese(II) complexes for application as contrast agents in magnetic resonance imaging [J].

Aime, S ;

Anelli, PL ;

Botta, M ;

Brocchetta, M ;

Canton, S ;

Fedeli, F ;

Gianolio, E ;

Terreno, E .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2002, 7 (1-2) :58-67

[2]

Aime S, 2000, ANGEW CHEM INT EDIT, V39, P747, DOI 10.1002/(SICI)1521-3773(20000218)39:4<747::AID-ANIE747>3.0.CO

[3]

2-2

[4] Redox outside the Box: Linking Extracellular Redox Remodeling with Intracellular Redox Metabolism [J].

Banerjee, Ruma .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (07) :4397-4402

[5]

Bard A.J., 2001, FUNDAMENTALS APPL

[6] Stereoisomers of Mn(III) complexes of ethylenebis[(o-hydroxyphenyl)glycine] [J].

Bihari, S ;

Smith, PA ;

Parsons, S ;

Sadler, PJ .

INORGANICA CHIMICA ACTA, 2002, 331 (01) :310-317

[7] In vivo monitoring of pH, redox status, and glutathione using L-band EPR for assessment of therapeutic effectiveness in solid tumors [J].

Bobko, Andrey A. ;

Eubank, Timothy D. ;

Voorhees, Jeffrey L. ;

Efimova, Olga V. ;

Kirilyuk, Igor A. ;

Petryakov, Sergey ;

Trofimiov, Dmitrii G. ;

Marsh, Clay B. ;

Zweier, Jay L. ;

Grigor'ev, Igor A. ;

Samouilov, Alexandre ;

Khramtsov, Valery V. .

MAGNETIC RESONANCE IN MEDICINE, 2012, 67 (06) :1827-1836

[8] Exploiting tumour hypoxia in cancer treatment [J].

Brown, JM ;

William, WR .

NATURE REVIEWS CANCER, 2004, 4 (06) :437-447

[9] Extracellular/Microenvironmental Redox State [J].

Chaiswing, Luksana ;

Oberley, Terry D. .

ANTIOXIDANTS & REDOX SIGNALING, 2010, 13 (04) :449-465

[10] Manganese(II) Complexes as Potential Contrast Agents for MRI [J].

Drahos, Bohuslav ;

Lukes, Ivan ;

Toth, Eva .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2012, (12) :1975-1986

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