Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease

被引：24

作者：

Liu, HC ^{[1
]}

Hong, CJ

Liu, CY

Lin, KN

Tsai, SJ

Liu, TY

Chi, CW

Wang, PN

机构：

[1] Taipei Vet Gen Hosp, Inst Neurol, Taipei, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan

[4] Chang Gung Univ Sch Med, Dept Psychiat, Taoyuan, Taiwan

[5] Chang Gung Mem Hosp, Taoyuan, Taiwan

[6] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2001年 / 55卷 / 04期

关键词：

Alzheimer's disease; depression; polymorphism; serotonin receptor 6 gene;

D O I：

10.1046/j.1440-1819.2001.00886.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A significant increase of 267C allele of the 5-HT6 receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers fur evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT6 genotype or allele distributions between the AD patients with depressive disorders (n=25) and those without (n=120) was not significant.

引用

页码：427 / 429

页数：3

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