DEVELOPMENT AND APPLICATION OF SPE/CZE METHOD FOR DETECTION AND DETERMINATION OF SELECTED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN WASTEWATER

被引：0

作者：

Capka, Lukas ^{[1
]}

Lacina, Petr ^{[2
]}

Vavrova, Milada ^{[2
]}

机构：

[1] Acad Sci Czech Republic, Inst Analyt Chem, Brno 61142, Czech Republic

[2] Brno Univ Technol, Fac Chem, Inst Chem & Technol Environm Protect, Brno 61200, Czech Republic

来源：

FRESENIUS ENVIRONMENTAL BULLETIN | 2012年 / 21卷 / 11A期

关键词：

Non-steroidal anti-inflammatory drugs; capillary zone electrophoresis; solid phase extraction; wastewater; CAPILLARY-ZONE-ELECTROPHORESIS; SOLID-PHASE EXTRACTION; CHROMATOGRAPHY-MASS SPECTROMETRY; PHARMACEUTICAL RESIDUES; LIQUID-CHROMATOGRAPHY; TREATMENT PLANTS; FATE; SAMPLES; ENVIRONMENT; REMOVAL;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study is focused on the development and application of reliable analytical method for detection and determination of selected acidic drugs from the group on non-steroidal anti-inflammatory drugs: acetaminophen (paracetamol), ibuprofen, naproxen, ketoprofen, diclofenac and salicylic acid. Applied method is based on solid phase extraction (SPE) and final analysis by capillary zone electrophoresis with detector of diode array (CZE-DAD). SPE/CZF, method is presented as a method applicable in the field of environmental analysis and monitoring of aquatic ecosystems. The method was successfully applied for the determination of selected drugs in wastewaters from the influent and effluent of wastewater treatment plant (WWTP) in Brno-Modrice, Czech Republic. Limits of detection are ranged from 0.46 to 1.28 mu g.L-1 depending on specific compound. Levels of concentrations of selected drugs are ranged from 0.61 to 42.80 mu g.L-1 in the influent and from 0.47 to 6.46 mu g.L-1 in the effluent of the WWTP.

引用

页码：3312 / 3317

页数：6

共 26 条

[1] Combination of solid-phase extraction and large-volume stacking with polarity switching in micellar electrokinetic capillary chromatography for the determination of traces of nonsteroidal anti-inflammatory drugs in saliva [J].

Almeda, Sara ;

Arce, Lourdes ;

Valcarcel, Miguel .

ELECTROPHORESIS, 2008, 29 (14) :3074-3080

[2] QUANTITATIVE-ANALYSIS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS BY CAPILLARY ZONE ELECTROPHORESIS [J].

BECHET, I ;

FILLET, M ;

HUBERT, P ;

CROMMEN, J .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (4-5) :497-503

[3] Occurrence and fate of pharmaceutically active compounds in the environment, a case study:: Hoje River in Sweden [J].

Bendz, D ;

Paxéus, NA ;

Ginn, TR ;

Loge, FJ .

JOURNAL OF HAZARDOUS MATERIALS, 2005, 122 (03) :195-204

[4]

Capka L, 2012, CHEM LISTY, V106, P30

[5] Capillary zone electrophoresis for simultaneous determination of seven nonsteroidal anti-inflammatory drugs in pharmaceuticals [J].

Chen, YL ;

Wu, SM .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005, 381 (04) :907-912

[6] Development and robustness testing of a nonaqueous capillary electrophoresis method for the analysis of nonsteroidal anti-inflammatory drugs [J].

Cherkaoui, S ;

Veuthey, JL .

JOURNAL OF CHROMATOGRAPHY A, 2000, 874 (01) :121-129

[7] Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry:: methods and preliminary results including toxicity studies with Vibrio fischeri [J].

Farré, ML ;

Ferrer, I ;

Ginebreda, A ;

Figueras, M ;

Olivella, L ;

Tirapu, L ;

Vilanova, M ;

Barceló, D .

JOURNAL OF CHROMATOGRAPHY A, 2001, 938 (1-2) :187-197

[8] Analytical methods for tracing pharmaceutical residues in water and wastewater [J].

Fatta, D. ;

Nikolaou, A. ;

Achilleos, A. ;

Meric, S. .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2007, 26 (06) :515-533

[9]

Fillet M, 1999, ELECTROPHORESIS, V20, P1907, DOI 10.1002/(SICI)1522-2683(19990701)20:9<1907::AID-ELPS1907>3.0.CO

[10]

2-L

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