Shape-shifting gametocytes: how and why does P-falciparum go banana-shaped?

被引:43
作者
Dixon, Matthew W. A. [1 ,2 ]
Dearnley, Megan K. [1 ,2 ]
Hanssen, Eric [2 ,3 ]
Gilberger, Tim [4 ,5 ,6 ]
Tilley, Leann [1 ,3 ]
机构
[1] Univ Melbourne, Dept Biochem & Mol Biol, Mol Sci & Biotechnol Inst Bio21, Melbourne, Vic 3010, Australia
[2] Univ Melbourne, ARC, Mol Sci & Biotechnol Inst Bio21, Ctr Excellence Coherent Xray Sci, Parkville, Vic 3010, Australia
[3] Univ Melbourne, Adv Microscopy Facil, Mol Sci & Biotechnol Inst Bio21, Parkville, Vic 3010, Australia
[4] Bernhard Nocht Inst Trop Med, Dept Mol Parasitol, Hamburg, Germany
[5] McMaster Univ, MG DeGroote Inst Infect Dis Res, Hamilton, ON, Canada
[6] McMaster Univ, Dept Pathol & Mol Med, Hamilton, ON, Canada
基金
英国医学研究理事会;
关键词
Plasmodium falciparum; gametocyte; inner membrane complex; deformability; splenic clearance; cytoadherence; RED-BLOOD-CELLS; ERYTHROCYTE DEFORMABILITY; MICROTUBULE INHIBITORS; MECHANICAL-PROPERTIES; TRANSMISSION STAGES; PARASITE PROTEINS; BONE-MARROW; MALARIA; ADHESION; GAMETOCYTOGENESIS;
D O I
10.1016/j.pt.2012.07.007
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Plasmodium falciparum is named for the crescent or falciform shape it adopts when preparing to undergo transfer to a mosquito vector. By contrast, gametocytes of the other (less virulent) human malaria parasites retain a more rounded shape. We describe the machinery that elongates falciparum gametocytes and discuss its relation with the machinery that elongates the invasive zoites. We address the question - why do falciparum malaria gametocytes go banana-shaped? The answer may lie in the finding that gametocyte maturation is associated with an increase in cellular deformability. The shape-shifting ability of gametocytes may facilitate the sequestration of early-stage gametocytes, while enabling late-stage gametocytes to circulate in the blood stream without being removed by the mechanical filtering mechanisms in the host spleen.
引用
收藏
页码:471 / 478
页数:8
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