SBA-15 tablet coated with HPMCP for pH-sensitive drug release system

被引：0
|
作者：
Xu Wu-Jun [1 ,2 ]
Gao Qing [1 ,2 ]
Xu Yao [1 ]
Wu Dong [1 ]
Sun Yu-Han [1 ]
机构：
[1] Chinese Acad Sci, Inst Cool Chem, State Key Lab Coal Convers, Taiyuan 030001, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
来源：
ACTA CHIMICA SINICA | 2008年 / 66卷 / 14期
关键词：
mesoporous material; pH-sensitive; drug release;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel pH-sensitive drug release system was fabricated by coating hydroxypropyl methylcellulose phthalate (HPMCP) on a drug-loaded SBA-15 tablet. Two kinds of release media, including simulated gastric fluid (SGF, pH=1.2) and simulated intestinal fluid (SIF, pH=7.5), were used to study the different drug release behavior of the system SBA-15/HPMCP. In SGF, due to the compact HPMCP coating on the SBA-15 tablet, the coating material could effectively delay the release rate of famotidine (Famo). But in SIF, because HPMCP could be quickly dissolved into the release medium, no obvious effect of the coating material on the drug delivery rate was found. Therefore, this novel system would have a potential application to targeting intestinal drug release.
引用
收藏
页码：1658 / 1662
页数：5
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