Somatic Stem Cells in the Myometrium and in Myomas

被引：13

作者：

Maruyama, Tetsuo ^{[1
]}

Ono, Masanori ^{[1
]}

Yoshimura, Yasunori ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Obstet & Gynecol, Shinjuku Ku, Tokyo 1608582, Japan

来源：

SEMINARS IN REPRODUCTIVE MEDICINE | 2013年 / 31卷 / 01期

基金：

日本学术振兴会;

关键词：

somatic stem cells; myomas (fibroids); hypoxia; pregnancy; myometrium; LABEL-RETAINING CELLS; UTERINE LEIOMYOMAS; SIDE POPULATION; STEM/PROGENITOR CELLS; SMOOTH-MUSCLE; BETA-CATENIN; CANCER; IDENTIFICATION; ACTIVATION; ETIOLOGY;

D O I：

10.1055/s-0032-1331801

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The human uterus mainly consists of two layers: an inner endometrium and an outer layer, the myometrium, made of smooth muscle. The uterus is characterized by its unique capacity for regeneration. This capacity permits cyclical regeneration and remodeling of the tissue over the course of a woman's reproductive life. During each menstrual cycle, the endometrium regenerates, and the uterus enlarges to make room for fetal growth. This cyclic physiologic pattern suggests that myometrial stem/progenitor cells are present in the tissue and play a role in myometrial functions. Our group (and others) recently characterized and isolated putative stem/progenitor cells in the myometrium. These findings are permitting a better understanding of myometrial physiology and pathology. We review current studies of myometrial stem/progenitor cells and suggestions that, in combination with hypoxia, these cells may contribute to uterine remodeling during pregnancy and the formation of myomas.

引用

页码：77 / 81

页数：5

共 40 条

[1] Conditional deletion of β-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium [J].