Designer drugs: a medicinal chemistry perspective

被引：106

作者：

Carroll, F. Ivy ^{[1
]}

Lewin, Anita H. ^{[1
]}

Mascarella, S. Wayne ^{[1
]}

Seltzman, Herbert H. ^{[1
]}

Reddy, P. Anantha ^{[1
]}

机构：

[1] Res Triangle Inst, Ctr Organ & Med Chem, Res Triangle Pk, NC 27709 USA

来源：

ADDICTION REVIEWS | 2012年 / 1248卷

关键词：

controlled substances; designer drugs; medicinal chemistry; opioids; analgesics; amphetamines; cannabinoids; PCP; stimulants; hallucinogens; DISCRIMINATIVE STIMULUS PROPERTIES; CANNABIMIMETIC INDOLES; BETA-PHENYLETHYLAMINE; CANNABINOID RECEPTOR; OPTICAL ISOMERS; ANALGESIC ACTIVITY; CLASSICAL CANNABINOIDS; PHENCYCLIDINE ANALOG; CB2; RECEPTORS; LEGAL HIGHS;

D O I：

10.1111/j.1749-6632.2011.06199.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

There are numerous medicinal chemistry reports in the literature describing the pharmacological properties of thousands of narcotics, stimulants, hallucinogens, sedative-hypnotic drugs, cannabinoids, and other psychoactive substances as well as synthetic methods for their preparations. This information, while essential for the advancement of science, has been used by clandestine chemists to manufacture and market an endless variety of analogs of so-called designer drugs. In this review, we describe how clandestine chemists used the principles of medicinal chemistry to design molecules, referred to as designer drugs, that elicit the effects of opioids, amphetamine and analogs, cannabinoids, and phencyclidine analogs while circumventing the law.

引用

页码：18 / 38

页数：21

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