Genetic variants on 17q21 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population

被引：18

作者：

Qiu, R. ^{[1
,2
]}

Zhang, H. ^{[3
]}

Zhao, H. ^{[1
,2
]}

Li, J. ^{[1
,2
]}

Guo, C. ^{[1
,2
]}

Gong, Y. ^{[1
,2
]}

Liu, Q. ^{[1
,2
]}

机构：

[1] Shandong Univ, Key Lab Expt Teratol, Minist Educ, Sch Med, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Dept Med Genet, Sch Med, Jinan 250012, Shandong, Peoples R China

[3] Shandong Acad Med Sci, Inst Basic Med, Jinan, Shandong, Peoples R China

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2013年 / 42卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ASTHMA; LOCI; DISEASE;

D O I：

10.3109/03009742.2013.786755

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: The aim of this study was to test whether orosomucoid like 3 (ORMDL3) and 17q21 variants are associated with susceptibility to ankylosing spondylitis (AS) in a Chinese population. Method: A total of 753 unrelated AS patients and 1120 ethnically matched healthy controls were recruited. Seven single nucleotide polymorphisms (SNPs: rs7216389, rs12603332, rs12936231, rs9303277, rs11557467, rs1007654, and rs17608925), which were selected from chromosome 17q21 containing the genes ORMDL3, GSDMB, ZPBP2, and IKZF3, were genotyped by the Taqman SNP genotyping assay. Results: Five of the SNPs (rs7216389, rs12603332, rs12936231, rs9303277, and rs11557467) were associated with AS (all p <= 0.01), especially in males (all p < 0.001). Of these, rs7216389, rs12603332, rs12936231, and rs11557467 were strongly associated with severity of the disease based on radiographic findings (p < 0.05). Conclusions: Our study confirmed that variants in chromosome 17q21 are significantly associated with AS in a Chinese Han population.

引用

页码：469 / 472

页数：4

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